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European Journal of Cancer

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May 2020

Volume 130p1-276

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Drug development

Safety and clinical efficacy of toripalimab, a PD-1 mAb, in patients with advanced or recurrent malignancies in a phase I study

Safety and clinical efficacy of toripalimab, a PD-1 mAb, in patients with advanced or recurrent malignancies in a phase I study

Jianliang Yang,
Lihou Dong,
Sheng Yang,
...
Yan Sun,
Haifeng Song,
Yuankai Shi

Published online: March 27, 2020

p182-192

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Breast cancer

Locoregional recurrence risk after neoadjuvant chemotherapy: A pooled analysis of nine prospective neoadjuvant breast cancer trials

Locoregional recurrence risk after neoadjuvant chemotherapy: A pooled analysis of nine prospective neoadjuvant breast cancer trials

Gustavo Werutsky,
Michael Untch,
Claus Hanusch,
...
Valentina Vladimirova,
Valentina Nekljudova,
Sibylle Loibl

Published online: March 13, 2020

p92-101

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Lung cancer

First-line pembrolizumab in advanced non–small cell lung cancer patients with poor performance status

First-line pembrolizumab in advanced non–small cell lung cancer patients with poor performance status

Francesco Facchinetti,
Giulia Mazzaschi,
Fausto Barbieri,
...
Roberta Camisa,
Massimo Di Maio,
Marcello Tiseo

Published online: March 25, 2020

p155-167

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Gastrointestinal oncology

Effect of apatinib plus neoadjuvant chemotherapy followed by resection on pathologic response in patients with locally advanced gastric adenocarcinoma: A single-arm, open-label, phase II trial

Effect of apatinib plus neoadjuvant chemotherapy followed by resection on pathologic response in patients with locally advanced gastric adenocarcinoma: A single-arm, open-label, phase II trial

Yanan Zheng,
Xiao Yang,
Chao Yan,
...
Min Yan,
Zhenggang Zhu,
Chen Li

Published online: March 11, 2020

p12-19

Open Access

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Korean red ginseng for cancer-related fatigue in colorectal cancer patients with chemotherapy: A randomised phase III trial

Korean red ginseng for cancer-related fatigue in colorectal cancer patients with chemotherapy: A randomised phase III trial

Jin Won Kim,
Sae Won Han,
Jae Yong Cho,
...
Dongbok Shin,
Jae Won Lee,
Yeul Hong Kim

Published online: March 12, 2020

p51-62

Open Access

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Guidelines for time-to-event end-point definitions in adjuvant randomised trials for patients with localised colon cancer: Results of the DATECAN initiative

Romain Cohen,
Dewi Vernerey,
Carine Bellera,
...
Qian Shi,
Thierry André
on behalf of the ACCENT Group

Published online: March 12, 2020

p63-71

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Diagnosing deficits in quality of life and providing tailored therapeutic options: Results of a randomised trial in 220 patients with colorectal cancer

Diagnosing deficits in quality of life and providing tailored therapeutic options: Results of a randomised trial in 220 patients with colorectal cancer

Monika Klinkhammer-Schalke,
Brunhilde Steinger,
Michael Koller,
...
Pompiliu Piso,
Patricia Lindberg-Scharf
for the Regensburg QoL Study Group

Published online: March 13, 2020

p102-113

Open Access

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Are tumour grade and tumour budding equivalent in colorectal cancer? A retrospective analysis of 771 patients

Are tumour grade and tumour budding equivalent in colorectal cancer? A retrospective analysis of 771 patients

Inti Zlobec,
Heather E. Dawson,
Annika Blank,
...
Martin D. Berger,
Iris D. Nagtegaal,
Alessandro Lugli

Published online: March 19, 2020

p139-145

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Older versus younger adults with gastric cancer receiving perioperative treatment: Results from the CRITICS trial

Older versus younger adults with gastric cancer receiving perioperative treatment: Results from the CRITICS trial

Astrid E. Slagter,
Benjamin Tudela,
Romy M. van Amelsfoort,
...
Edwin P.M. Jansen,
Annemieke Cats,
Marcel Verheij

Published online: March 21, 2020

p146-154

Open Access

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$Randomised phase II trial (SWOG S1310) of single agent MEK inhibitor trametinib Versus 5-fluorouracil or capecitabine in refractory advanced biliary cancer$

Randomised phase II trial (SWOG S1310) of single agent MEK inhibitor trametinib Versus 5-fluorouracil or capecitabine in refractory advanced biliary cancer

Richard D. Kim,
Shannon McDonough,
Anthony B. El-Khoueiry,
...
Katherine A. Guthrie,
Milind Javle,
Howard Hochster

Published online: March 29, 2020

p219-227

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Urologic oncology

Concomitant intake of abiraterone acetate and food to increase pharmacokinetic exposure: real life data from a therapeutic drug monitoring programme

Concomitant intake of abiraterone acetate and food to increase pharmacokinetic exposure: real life data from a therapeutic drug monitoring programme

Stefanie L. Groenland,
Merel van Nuland,
Andries M. Bergman,
...
Alwin D.R. Huitema,
Neeltje Steeghs
On behalf of the Dutch Pharmacology Oncology Group (DPOG)

Published online: March 12, 2020

p32-38

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Gynecologic oncology

Comparison of survival between primary debulking surgery and neoadjuvant chemotherapy for stage III/IV ovarian, tubal and peritoneal cancers in phase III randomised trial

Comparison of survival between primary debulking surgery and neoadjuvant chemotherapy for stage III/IV ovarian, tubal and peritoneal cancers in phase III randomised trial

Takashi Onda,
Toyomi Satoh,
Gakuto Ogawa,
...
Toshiharu Kamura,
Hiroyuki Yoshikawa
on behalf of Japan Clinical Oncology Group

Published online: March 13, 2020

p114-125

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Practical clinical guidelines of the EOTTD for treatment and referral of gestational trophoblastic disease

Practical clinical guidelines of the EOTTD for treatment and referral of gestational trophoblastic disease

Christianne Lok,
Nienke van Trommel,
Leon Massuger,
François Golfier,
Michael Seckl
on behalf of the Clinical Working Party of the EOTTD

Published online: April 01, 2020

p228-240

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Head and neck oncology

A prospective multicentre REFCOR study of 470 cases of head and neck Adenoid cystic carcinoma: epidemiology and prognostic factors

A prospective multicentre REFCOR study of 470 cases of head and neck Adenoid cystic carcinoma: epidemiology and prognostic factors

Sarah Atallah,
Odile Casiraghi,
Nicolas Fakhry,
...
Esteban Brenet,
Anne Aupérin,
Bertrand Baujat

Published online: March 11, 2020

p241-249

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Should a neck dissection be performed on patients with cN0 adenoid cystic carcinoma? A REFCOR propensity score matching study

Should a neck dissection be performed on patients with cN0 adenoid cystic carcinoma? A REFCOR propensity score matching study

Sarah Atallah,
Antoine Moya-Plana,
Olivier Malard,
...
Esteban Brenet,
Benjamin Verillaud,
Bertrand Baujat

Published online: January 30, 2020

p250-258

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Melanoma and skin cancers

Survival of patients with advanced metastatic melanoma: The impact of MAP kinase pathway inhibition and immune checkpoint inhibition - Update 2019

Survival of patients with advanced metastatic melanoma: The impact of MAP kinase pathway inhibition and immune checkpoint inhibition - Update 2019

Selma Ugurel,
Joachim Röhmel,
Paolo A. Ascierto,
...
Lisa Zimmer,
Dirk Schadendorf,
Claus Garbe

Published online: March 13, 2020

p126-138

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Characterization of risk factors and efficacy of medical management of immune-related hepatotoxicity in real-world patients with metastatic melanoma treated with immune checkpoint inhibitors

Characterization of risk factors and efficacy of medical management of immune-related hepatotoxicity in real-world patients with metastatic melanoma treated with immune checkpoint inhibitors

Nicole A. Romanski,
Rikke B. Holmstroem,
Eva Ellebaek,
Inge Marie Svane

Published online: March 28, 2020

p211-218

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Pediatric oncology

Outcomes of metastatic non-rhabdomyosarcoma soft tissue sarcomas (NRSTS) treated within the BERNIE study: a randomised, phase II study evaluating the addition of bevacizumab to chemotherapy

Outcomes of metastatic non-rhabdomyosarcoma soft tissue sarcomas (NRSTS) treated within the BERNIE study: a randomised, phase II study evaluating the addition of bevacizumab to chemotherapy

Andrea Ferrari,
Johannes H.M. Merks,
Julia C. Chisholm,
...
Hubert N. Caron,
Gian Luca De Salvo,
Michela Casanova

Published online: March 13, 2020

p72-80

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Systematic target actionability reviews of preclinical proof-of-concept papers to match targeted drugs to paediatric cancers

Systematic target actionability reviews of preclinical proof-of-concept papers to match targeted drugs to paediatric cancers

Nil A. Schubert,
Caitlin D. Lowery,
Guillaume Bergthold,
...
Stefan M. Pfister,
Hubert N. Caron,
Jan J. Molenaar

Published online: March 27, 2020

p168-181

Open Access

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Epidemiology and prevention

Age-, sex- and disease subtype–related foetal growth differentials in childhood acute myeloid leukaemia risk: A Childhood Leukemia International Consortium analysis

Maria A. Karalexi,
Nick Dessypris,
Xiaomei Ma,
...
Catherine Metayer,
Elizabeth Milne,
Eleni Th Petridou

Published online: March 09, 2020

p1-11

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A population-based study on intestinal and diffuse type adenocarcinoma of the oesophagus and stomach in the Netherlands between 1989 and 2015

A population-based study on intestinal and diffuse type adenocarcinoma of the oesophagus and stomach in the Netherlands between 1989 and 2015

Rosa T. van der Kaaij,
Willem J. Koemans,
Margreet van Putten,
...
Valery E.P.P. Lemmens,
Rob H.A. Verhoeven,
Johanna W. van Sandick

Published online: March 11, 2020

p23-31

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Improved survival in patients with head and neck cancer treated in higher volume centres: A population-based study in Belgium

Improved survival in patients with head and neck cancer treated in higher volume centres: A population-based study in Belgium

Roos Leroy,
Geert Silversmit,
Sabine Stordeur,
...
Jan Vermorken,
Vincent Grégoire,
Sandra Nuyts

Published online: March 13, 2020

p81-91

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Patients' education level and treatment modality for prostate cancer in the Finnish Randomized Study of Screening for Prostate Cancer

Tuomas P. Kilpeläinen,
Kirsi Talala,
Kimmo Taari,
...
Juho Pylväläinen,
Teuvo LJ. Tammela,
Anssi Auvinen

Published online: March 28, 2020

p204-210

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Tumour Immunology and Immunotherapy

The 2016–2019 ImmunoTOX assessment board report of collaborative management of immune-related adverse events, an observational clinical study

The 2016–2019 ImmunoTOX assessment board report of collaborative management of immune-related adverse events, an observational clinical study

Jean-Marie Michot,
Ariane Lappara,
Jérôme Le Pavec,
...
Aurélien Marabelle,
Stéphane Champiat,
Olivier Lambotte

Published online: March 12, 2020

p39-50

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Emergency presentations in patients treated with immune checkpoint inhibitors

Emergency presentations in patients treated with immune checkpoint inhibitors

Tim Cooksley,
Avinash Gupta,
Tamer Al-Sayed,
Paul Lorigan

Published online: March 27, 2020

p193-197

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Human leucocyte antigen DR15, a possible predictive marker for immune checkpoint inhibitor–induced secondary adrenal insufficiency

Seiichi Yano,
Kenji Ashida,
Ryuichi Sakamoto,
...
Yoichi Nakanishi,
Masatoshi Nomura,
Yoshihiro Ogawa

Published online: March 28, 2020

p198-203

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Correspondence

Diffuse large B-cell lymphoma after nivolumab treatment for lung cancer: A case report and a World Health Organization pharmacovigilance database review

Pascaline Boudou-Rouquette,
Eric Grignano,
Jennifer Arrondeau,
Barbara Burroni,
Laurent Chouchana

Published online: March 11, 2020

p20-22

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Re: Deep learning outperformed 11 pathologists in the classification of histopathological melanoma images

Cyrill Géraud,
Klaus G. Griewank

Published online: October 23, 2019

p259-261

Open Access

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Reply to the letter to the editor: ‘Deep learning outperformed 11 pathologists in the classification of histopathological melanoma images’

Achim Hekler,
Jochen S. Utikal,
Wiebke Solass,
...
Christof von Kalle,
Stefan Fröhling,
Titus J. Brinker

Published online: January 30, 2020

p262-264

Open Access

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Re: A multicentre retrospective cohort study of ovarian germ cell tumours: Evidence for chemotherapy de-escalation and alignment of paediatric and adult practice

Farzana Pashankar,
A. Lindsay Frazier

Published online: March 13, 2020

p265-266

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Response to: A multicentre retrospective cohort study of ovarian germ cell tumours: Evidence for chemotherapy de-escalation and alignment of paediatric and adult practice

Daniel M. Berney,
Jonathan Shamash,
Sara Stoneham,
Michelle Lockley

Published online: March 18, 2020

p267-268

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Atypical extended immune-related neutropenia in patient treated with pembrolizumab

Atypical extended immune-related neutropenia in patient treated with pembrolizumab

Pierre-Antoine Laurain,
Térence Landrin,
Sami Souidi,
Philippe Beuzeboc,
Florian Scotté

Published online: March 17, 2020

p269-271

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Hepatitis B flare during osimertinib targeted therapy in a lung cancer patient with a resolved hepatitis B virus infection

Po-Hsin Lee,
Teng-Yu Lee,
Gee-Chen Chang

Published online: March 20, 2020

p272-274

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Errata

Erratum to ‘Erythrocyte-encapsulated asparaginase (eryaspase) combined with chemotherapy in second-line treatment of advanced pancreatic cancer: An open-label, randomized Phase IIb trial’ [European Journal of Cancer, Volume 124 (January 2020) Pages 91-101]

Pascal Hammel,
Fabienne Portales,
Laurent Mineur,
...
Anu Gupta,
Jean-Baptiste Bachet,
Iman El Hariry

Published online: March 06, 2020

p275-276

Open Access

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