March 2019

Table of Contents

Aged neutrophils fuel tumor progression

• C.A. Reichel,
• L.A. Mittmann,
• J.B. Schaubaecher,
• R. Hennel,
• K. Lauber,
• B. Uhl

Overall responses and survival in RCC on pegilodecakin with anti-PD-1

• A. Naing,
• J.R. Infante,
• D.J. Wong,
• ...
• P. Van Vlasselaer,
• M. Tannir,
• M. Oft

A plasma-based assay for assessment of tumour mutational burden in patients with metastatic non-small cell lung cancer in the first-line treatment setting: Results from the MYSTIC study

• H. Si,
• M. Kuziora,
• E. Helman,
• ...
• R. Raja,
• K. Ranade,
• B.W. Higgs

Late-differentiated effector neoantigen-specific CD8+ T cells are enriched in non-small cell lung carcinoma patients responding to atezolizumab treatment

• M. Fehlings,
• A. Nardin,
• S. Jhunjhunwala,
• ...
• M. Ballinger,
• E. Newell,
• M. Yadav

Characterization of bispecific antibodies that drive synthetic agonistic receptor - transduced T cells to mediate specific and conditional therapy in human pancreatic cancer models

• M. Benmebarek,
• C.H. Karches,
• M.L. Schmidbauer,
• ...
• S. Endres,
• C. Klein,
• S. Kobold

A screening for novel immune-checkpoints identifies a serine/threonine kinase to confer immune resistance in multiple myeloma

• V. Volpin,
• T. Michels,
• A. Sorrentino,
• ...
• M. Ehrenschwender,
• M. Witzens-Harig,
• P. Beckhove

Immune and mutational landscape in triple negative breast cancer and its evolution during neoadjuvant chemotherapy associated or not with GTN and anti-PD-1

• N. Mabrouk,
• C. Racoeur,
• L. Dondaine,
• ...
• L. Chouchane,
• A. Bettaieb,
• C. Paul

In-situ diversification of immunity following vaccination targeting tumor neoepitopes; an integral component of combinatorial immunotherapy

• K.L. Lee,
• C. Palena,
• J. Lee,
• ...
• P. Soon-Shiong,
• J. Schlom,
• D.H. Hamilton

Histone deacetylase inhibitors valproic acid and vorinostat enhance trastuzumab-mediated antibody-dependent cell-mediated phagocytosis

• J. Laengle,
• J. Kabiljo,
• J. Homola,
• L. Hunter,
• G. Egger,
• M. Bergmann

LL-37 inhibits pancreatic cancer development through inhibition of autophagy and reprogramming of the tumor microenvironment

• J.K. Ko,
• Z. Zhang

Tissue slice culture platform: A slice of reality in drug development

• F. Garcon,
• S. Burke,
• K. Ryan,
• J. Harper,
• R.W. Wilkinson

Omental fat in ovarian cancer induces lymphangiogenesis – The role of an adipose-rich microenvironment in tumor progression and metastatic dissemination

• V.F. Starrach,
• B. Lenoir,
• D. Ferber,
• ...
• I. Zörnig,
• D. Jäger,
• N. Halama

Reprogramming of M2-like macrophages to M1-like phenotype by tumor-antigen specific CD4+ T cells

• D. Eisel,
• K. Das,
• R. König,
• W. Osen,
• S.B. Eichmüller

Myeloid cells mediates the accelerated growth of tumor in high-fat diet-fed mice

• T. Tran,
• M. Montabord,
• B. Esposito,
• T. Tedgui,
• E. Tartour,
• S. Potteaux

The panta rhei of breast cancer: Gene expression timeline analysis during progression of microinvasive breast cancer microenvironment

• F. Lessi,
• C. Scatena,
• P. Aretini,
• ...
• S. Franceschi,
• A. Naccarato,
• C. Mazzanti

Immunogenic effects of FOLFOXIRI plus Bevacizumab therapy in colorectal peritoneal carcinomatosis

• H. Birnleitner,
• M. Sachet,
• T. Bachleitner-Hofmann,
• R. Oehler

Differences in macrophage colonization of the colorectal cancer and normal mucosa

• K. Strasser,
• N. Walterskirchen,
• M. Sachet,
• ...
• A. Stift,
• M. Bergmann,
• R. Oehler

Comparing the immune cell infiltration of colorectal cancer with distant normal mucosa uncovers a prognostically relevant immune cell profile

• K. Strasser,
• H. Birnleitner,
• A. Beer,
• ...
• A. Stift,
• M. Bergmann,
• R. Oehler

Probing the interaction of macrophages in the pancreatic cancer microenvironment using 3D engineered rollable tumour (TRACER)

• I. Co,
• T. McGaha,
• A.P. McGuigan

In contrast to other soft tissue sarcomas, GIST shows enhanced numbers of immune checkpoint-negative CD8 T cells

• Y. Klaver,
• C.H.J. Lamers,
• M. Rijnders,
• ...
• K. Verhoef,
• S. Sleijfer,
• R. Debets

Cholesterol induces CD8⁺ T-cell exhaustion in the tumor microenvironment

• Q. Yi

Establishing of a primary cancer microtissue model to investigate immune cell infiltration

• S. Koeck,
• M. Zwierzina,
• G. Gamerith,
• E. Lorenz,
• H. Zwierzina,
• A. Amann

The nonessential amino acid proline enhances migration and proliferation of human melanoma cells

• K. Mayr,
• C. Wasinger,
• S. Mayer,
• M. Hohenegger

Glycosylation of the cytokine co-receptor gp130 reveals a rapid protein turnover, which gives raise to biased signalling in human melanoma cells from different disease stages

• K. Svoboda,
• C. Wasinger,
• S. Mayer,
• M. Hohenegger

Lipid-storing, tumor-associated macrophages orchestrate a tumor-excluded immune landscape in omentum metastases of epithelial ovarian cancer

• M. Suarez-Carmona,
• N.A. Valous,
• B.M.A. Lenoir,
• ...
• I. Zörnig,
• D. Jäger,
• N. Halama

Clearance of apoptotic bodies by neutrophils induce tissue regenerative responses

• V. Brandel,
• M. Sachet,
• V. Schimek,
• P. Starlinger,
• A. Assinger,
• R. Oehler

Cancer associated mast cells exhibit a tumor promoting phenotype but can be effectively targeted to reinvigorate antitumor immunity in a human based ex-vivo model

• D. Ferber,
• M. Suarez-Carmona,
• B. Lenoir,
• ...
• I. Zörnig,
• D. Jäger,
• N. Halama

Multispectral imaging for quantitative and compartment specific immune profiling of cancer tissue

• B. Wendik,
• M. Backmann,
• P. Micke,
• A. Mezheyeuski

Induction of tumor-specific immune responses by the TLR9 agonist EnanDIM in murine syngeneic tumor models

• B. Volz,
• K. Kapp,
• D. Oswald,
• B. Wittig,
• M. Schmidt

Targeting a membrane-proximal epitope on mesothelin increases the tumoricidal activity of a bispecific antibody blocking CD47 on tumor cells

• E. Hatterer,
• X. Chauchet,
• L. Barba,
• ...
• W. Ferlin,
• V. Buatois,
• L. Shang

3D micro-tumors for predicting individual treatment responses to immunotherapy

• T. Sturmheit,
• H. Stamm,
• I. Stange,
• ...
• W. Fiedler,
• J. Kupper,
• A. Block

HDAC6 inhibitor ITF3791 enhances alloantigen presentation capabilities of myeloid cells modulating PD-L1 expression and co-stimulatory molecules

• C. Ripamonti,
• C. Steinkuhler,
• E. Cellupica,
• G. Fossati

Induction of a strong and persistent antitumor immune response using liposomal vaccines in the HPV-transformed orthotopic lung tumor model TC-1

• C. Jacoberger-Foissac,
• B. Frisch,
• V. Flacher,
• B. Heurtault,
• S. Fournel

Oncolysis dominated therapeutic effect of LCMV-GP – pseudotyped vesicular stomatitis virus in a syngeneic lung cancer model

• L. Schreiber,
• C. Urbiola,
• B. Spiesschaert,
• ...
• M. Petersson,
• D. von Laer,
• G. Wollmann

Expression of Indoleamine 2,3-dioxygenase in erlotinib-treated patients with advanced pancreatic cancer: Translational results from a multi-center, randomized phase III trial

• S. Kruger,
• S. Ormanns,
• V. Roesgen,
• ...
• M. von Bergwelt-Baildon,
• V. Heinemann,
• S. Boeck

Prevention of tumor ulceration in mice – Mammary fat pad injection of tumor cells

• C. Obodozie,
• J. Beshay,
• B. Stahnke,
• ...
• B. Giesen,
• U. Leisegang,
• H. Weber

Identification and evaluation of novel sarcoma antigens for use with oncolytic vaccines

• H. Birdi,
• F. Tzelepis,
• M. Hooshyar,
• J. Werier,
• J. Diallo

Immune-related effects of the ETS factor inhibitor YK-4-279

• C. Dinhof,
• D. Baier,
• P. Kroiss,
• C. Pirker,
• W. Berger

Mechanism of action of NKTR-214, a first-in-class, CD122-preferential IL-2 pathway agonist

• W.W. Overwijk

The phytochemicals Curcumin and Vitamin C act as immunosensitizer

• M. Luzbetak,
• N. Süßenguth,
• J. Werner,
• B. Mayer

An oncolytic influenza A virus expressing the mycobacterial ESAT-6 protein

• V. Lazlo,
• J. Kabiljo,
• S. Török,
• ...
• B. Dome,
• A. Egorov,
• M.M. Bergmann

Development of an in vitro 3D model system for testing PD-1/PDL-1 immune checkpoint inhibitors

• F. Chiovaro,
• N. Buschmann,
• S. Strebel,
• P. Guye,
• I. Agarkova

Interlaboratory variation in PD-L1 positivity in non-small cell lung cancer patients: a nationwide study

• B.M. Koomen,
• Q.J.M. Voorham,
• I.A.G. Deckers,
• S.M. Willems

MiRNA deregulation can contribute to breakdown of MHC I class antigen processing and presenting machinery in breast cancer cells

• V.A. Halytskiy

Modulated electro hyperthermia as an immune modulator with checkpoint inhibitors and radiotherapy

• C.A. Minnaar,
• J.A. Kotzen

Comparison of three PD-L1 immunohistochemical assays in head and neck squamous cell carcinoma

• E.J. de Ruiter,
• F. Mulder,
• E. Speel,
• ...
• E. Bloemena,
• L. Devriese,
• S. Willems

Study of IDO1 gene expression in histological variants of colorectal carcinoma

• M.C. Turpín Sevilla,
• J. García-Solano,
• I. Gutierrez-García,
• ...
• D. Torres-Moreno,
• B. Alburquerque-González,
• P. Conesa-Zamora

Phase I trial of combination dendritic vaccine and immune checkpoint blockade for prevention of postoperative glioblastoma recurrence

• L. Chen,
• T. Liu,
• H. Liu,
• ...
• S. Shen,
• L. Yang,
• X. Yu

Characterisation of peripheral blood mononuclear cells in patients with combination ipilimumab and nivolumab therapy-related colitis

• S.C. Sasson,
• J. Zaunders,
• K. Nahar,
• ...
• G.V. Long,
• A.M. Menzies,
• A.D. Kelleher