March 2015

Abstract only

ITOC2 – 001. Influence of tumour cell – Fibroblast co-culture on monocyte differentiation and tumour growth in pancreatic cancer
• Findeis J.F. Janina,
• Majety M.M. Meher
Published in issue: March 2015
S1
ITOC2 – 002. Immunosuppressive microenvironment in pancreatic adenocarcinoma
• Karakhanova Svetlana,
• Werner Jens,
• Bazhin V. Alexandr
Published in issue: March 2015
S1
ITOC2 – 003. Store-operated calcium signaling in EGF-mediated COX-2 inflammatory gene activation in cancer cells
• Wang Jaw Yuan
Published in issue: March 2015
S2
ITOC2 – 004. Imaging in cancer immunology: Phenotyping of multiple immune cell subsets in situ in FFPE tissue sections
• Mansfield R. James,
• Wendik Bjoern,
• Hoyt Cliff,
• ...
• Fox Bernie,
• Bifulco Carlo,
• Byers Richard
Published in issue: March 2015
S2
ITOC2 – 005. Humanized mouse models for preclinical testing of antitumour immune therapy
• Wulf-Goldenberg Annika,
• Stecklum Maria,
• Fichtner Iduna,
• Hoffmann Jens
Published in issue: March 2015
S2
ITOC2 – 006. Notch triggers myeloid reprogramming in murine pancreatic cancer
• Neff Florian,
• Kirsch G. David,
• Saur Dieter,
• Schmid M. Roland,
• Heikenwälder F. Mathias,
• Siveke T. Jens
Published in issue: March 2015
S2-S3
ITOC2 – 007. Two immune faces of pancreatic adenocarcinoma: Impact of immunosuppression
• Bazhin V. Alexandr,
• Werner Jens,
• Karakhanova Svetlana
Published in issue: March 2015
S3
ITOC2 – 008. Melanoma differentiation-associated protein 5 (MDA5)-based tumour immunotherapy reprograms M2/G2-polarised myeloid-derived suppressor cells (MDSCs)
• Kirchleitner V. Sabrina,
• Schrom Eva,
• Endres Stefan,
• Düwell Peter,
• Schnurr Max
Published in issue: March 2015
S3
ITOC2 – 009. Role of signal transduction and microRNAs on the immunogenicity of melanoma cells
• Meyer Stefanie,
• Donia Marco,
• Handke Diana,
• ...
• Meinhardt Anne,
• Jasinski-Bergner Simon,
• Bukur Juergen
Published in issue: March 2015
S3
ITOC2 – 010. Virotherapy overcomes tumour resistance to PD1-immunotherapy by broad mutanome-directed T cell responses
• Woller Norman,
• Gürlevik Engin,
• Fleischmann-Mundt Bettina,
• ...
• Manns P. Michael,
• Kubicka Stefan,
• Kühnel Florian
Published in issue: March 2015
S4
ITOC2 – 011. Identification of second-generation potent and selective inhibitors of indoleamine-2,3-dioxygenase-1 (IDO1) for the treatment of cancer
• Jaen C. Juan,
• Bjorck Pia,
• Fridman S. Jordan,
• ...
• Walters J. Matthew,
• Zibinsky Mikhail,
• Powers P. Jay
Published in issue: March 2015
S4
ITOC2 – 012. Neoadjuvant immune checkpoint blockade for pancreatic cancer prevents local tumour recurrence through tissue resident antitumoural CD8+ CD103+ T cells
• Brooks Jennifer,
• Fleischmann-Mundt Bettina,
• Woller Norman,
• Kubicka Stefan,
• Kühnel Florian,
• Gürlevik Engin
Published in issue: March 2015
S4-S5

ITOC2 – 013. In vitro kynurenine modulation by novel dual-acting and selective TDO and IDO inhibitors
• Wise Alan,
• Mcguinness E. Barry,
• Cowley M. Phillip,
• ...
• Bevan Nicola,
• Szybut Clare,
• Brown J. Thomas
Published in issue: March 2015
S5
ITOC2 – 014. Immunomodulation of blasts in AML-patients (AML-pts) with clinically approved response modifiers to improve antileukemic T-cell reactivity: An ex vivo simulation of the clinical
• Schmetzer Helga,
• Stankova Zuzanna,
• Deen Diana,
• ...
• Wendtner Clemens,
• Schmid Christoph,
• Tischer Johanna
Published in issue: March 2015
S5
ITOC2 – 015. Therapy of hepatocellular carcinoma (HCC) with immunostimulatory RNA activating RIG-I
• Posselt Laura,
• Lazic Igor,
• Boehmer Daniel,
• ...
• Duewell Peter,
• Rothenfußer Simon,
• Schnurr Max
Published in issue: March 2015
S5-S6
ITOC2 – 016. Effective vaccination against melanoma in an animal study: Combination of laser-assisted dermal skin delivery and cross-presenting XCR1+ dermal DCs targeting
• Terhorst D.T. Dora,
• Fossum E.F. Even,
• Baranska A.B. Anna,
• ...
• Bogen B.B. Bjarne,
• Malissen B.M. Bernard,
• Henri S.H. Sandrine
Published in issue: March 2015
S6
ITOC2 – 017. Prolonged survival for patients with recurrent glioblastoma multiforme who are treated with tumour lysate-pulsed autologous dendritic cells
• Bosch L. Marnix,
• Prins M. Robert,
• Liau Linda
Published in issue: March 2015
S6-S7
ITOC2 – 018. Hyperthermia induced immunogenic cell-death
• Andocs Gabor,
• Meggyeshazi Nora,
• Vancsik Tamas,
• ...
• Papp Edina,
• Kovago Csaba,
• Szasz Oliver
Published in issue: March 2015
S7
ITOC2 – 019. An open-label multicenter phase II trial of aviscumine in previously treated patients with unresectable stage IV metastatic melanoma
• Trefzer Uwe,
• Gutzmer Ralf,
• Wilhelm Tabea,
• ...
• Witthohn Klaus,
• Lentzen Hans,
• Mohr Peter
Published in issue: March 2015
S7
ITOC2 – 020. VGX-3100 Immunotherapy for CIN2/3 Induces regression of cervical lesions and viral clearance (Phase II study): Implications for treatment of HPV associated cancers
• Sardesai Niranjan,
• Trimble Cornelia,
• Morrow Matthew,
• ...
• Yan Jian,
• Lee Jessica,
• Bagarazzi Mark
Published in issue: March 2015
S7-S8
ITOC2 – 021. The melanoma immune-peptidome for T-cell-based anti-tumour immunotherapies
• Bassani-Sternberg Michal,
• Bräunlein Eva,
• Klar Richard,
• ...
• Busch H. Dirk,
• Mann Matthias,
• Krackhardt M. Angela
Published in issue: March 2015
S8
ITOC2 – 022. Vaccination with next-generation dendritic cells for AML postremission therapy induces antigen-specific T cell responses
• Schnorfeil Frauke,
• Lichtenegger Felix,
• Geiger Christiane,
• ...
• Schendel Dolores,
• Hiddemann Wolfgang,
• Subklewe Marion
Published in issue: March 2015
S8
ITOC2 – 023. Integrated computational pipeline for development of personalised melanoma vaccine
• Jaitly Tanushree,
• Gupta Dr. Shailendra,
• Dorrie Dr. Jan,
• ...
• Schaft Dr. Neils,
• Schuler-Thurner Dr. Beatrice,
• Schuler Pr. Gerold
Published in issue: March 2015
S8-S9
ITOC2 – 024. Selective lysis of biphenotypic leukaemia cells is mediated by dual-targeting triplebody 33-3-19 treatment
• Roskopf C. Claudia,
• Braciak A. Todd,
• Fenn Nadja,
• ...
• Fey H. Georg,
• Hopfner Karl-Peter,
• Oduncu S. Fuat
Published in issue: March 2015
S9
ITOC2 – 025. Transduction with C-C-chemokine receptor type 4 (CCR4) enhances tumour-specific migration of adoptively transferred T cells in a model of pancreatic cancer
• Rapp Moritz,
• Grassmann Simon,
• Endres Stefan,
• Anz David,
• Kobold Sebastian
Published in issue: March 2015
S9
ITOC2 – 026. A new fusion receptor overcomes PD-1-mediated immunosuppression in adoptive T cell therapy
• Kobold Sebastian,
• Grassmann Simon,
• Chaloupka Michael,
• ...
• Rothenfusser Simon,
• Schnurr Max,
• Endres Stefan
Published in issue: March 2015
S9-S10
ITOC2 – 027. Redirecting adenovirus-specific T cells by a tumour-specific T cell receptor for therapy of hepatocellular carcinoma
• Ureche I. Cristina,
• Guerlevik Engin,
• Woller Norman,
• ...
• Manns P. Michael,
• Kubicka Stefan,
• Kuehnel Florian
Published in issue: March 2015
S10
ITOC2 – 028. Transgenic antigen-specific, allogeneic HLA-A^∗0201-restricted cytotoxic T cells recogniae tumour-associated target antigen STEAP1 with high specificity
• Schirmer David,
• Busch H. Dirk,
• Uckert Wolfgang,
• ...
• Klar Richard,
• Burdach Stefan,
• Richter HS. Günther
Published in issue: March 2015
S10
ITOC2 – 029. Combination of CTLA4-blockade, depletion of CD25+ cells and active-specific immunotherapy prolongs survival in murine melanoma
• Kovács R. Julia,
• Rose Peter,
• Boon Louis,
• Hatz A. Rudolf,
• Winter Hauke,
• Van Den Engel K. Natasja
Published in issue: March 2015
S10-S11
ITOC2 – 030. Identification of the neoantigen Ndufs1-V491A for investigations on immunotherapies in murine tumour models
• Schumacher Anja,
• Woller Norman,
• Knocke Sarah,
• ...
• Fleischmann-Mundt Bettina,
• Manns P. Michael,
• Kühnel Florian
Published in issue: March 2015
S11
ITOC2 – 031. Immunomodulatory characteristics of Resminostat, a novel HDAC inhibitor in phase II clinical development
• Hamm Svetlana,
• Prenzel Tanja,
• Henning Stefan
Published in issue: March 2015
S11
ITOC2 – 032. Optimising active-specific immunotherapy in lymphodepleted mice with subcutaneous melanoma
• Rose Peter,
• Kovács R. Julia,
• Boon Louis,
• Hatz A. Rudolf,
• Winter Hauke,
• van den Engel K. Natasja
Published in issue: March 2015
S11
ITOC2 – 033. Influence of interferon-alpha combined with chemo (radio) therapy on immunological parameters in pancreatic adenocarcinoma
• Karakhanova Svetlana,
• Werner Jens,
• Bazhin V. Alexandr
Published in issue: March 2015
S12
ITOC2 – 034. Development of a 3D cell culture model for the investigation of cancer cell/immune cell interactions
• Köck Stefan,
• Zwierzina Marit,
• Huber Julia,
• ...
• Knab Annabella,
• Zwierzina Heinz,
• Amann Arno
Published in issue: March 2015
S12
ITOC2 – 035. The immunotherapeutic TLR-9 agonist MGN1703 – Pharmacokinetic and pharmacodynamic data from healthy volunteers and cancer patients
• Schmidt Manuel,
• Kapp Kerstin,
• Oswald Detlef,
• Schroff Matthias,
• Wittig Burghardt,
• Zurlo Alfredo
Published in issue: March 2015
S12
ITOC2 – 036. A method for developing predictive tests for immunotherapy benefit
• Roder Heinrich,
• Roder Joanna
Published in issue: March 2015
S12-S13
ITOC2 – 037. CEA TCB, A novel T-cell bispecific antibody with potent in vitro and in vivo antitumour activity against solid tumours
• Marina Bacac,
• Tanja Fauti,
• Sara Colombetti,
• ...
• Vaios Karanikas,
• Christian Klein,
• Pablo Umaña
Published in issue: March 2015
S13
ITOC2 – 038. Role of exosomes in immune suppression
• Veronica Huber,
• Viviana Vallacchi,
• Lorenza Di Guardo,
• ...
• Valentina Bollati,
• Monica Rodolfo,
• Licia Rivoltini
Published in issue: March 2015
S13