POSTER SESSION 18 November 2022: Basic Science and Translational Research| Volume 175, SUPPLEMENT 1, S80, November 2022

A higher number of HSP70 positive immune cells in a deep layer of TNBC is associated with a higher FOXP3 expression and a higher risk of axillary lymph node involvement

      Background: The high mutation burden of triple-negative breast cancer (TNBC) is related to its immunogenic potential. The presence of tumour infiltrating lymphocytes (TILs) in the preclinical stage of disease reflects a proinflammatory immune response against cancer cells. However, cancer cells may modulate it to support tumour growth and progression. A chaperone HSP70 molecule expression, upregulated by oncogenic signalling, supports the formation of early-stage breast cancer (BC) as well. Moreover, in the later course of the disease, HSP70 is actively released by the cancer cells and can induce the termination of the specific immune response. The aim of this study was to explore the role and possible predictive value of the HSP70(+) immune cells in a deep layer (HSP70-IC-DL) of TNBC.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to European Journal of Cancer
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect