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Re: Effect of glioma-derived immunoglobulin on biological function of glioma cells: The emerging roles of immunoglobulins in the tumor immune microenvironment

  • Fei Wu
    Correspondence
    Corresponding author: Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, No.440 Jiyan Road, Jinan, 250117, PR China. Tel.: +86 15628939788; fax: +531 87984079.
    Affiliations
    Department of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China

    Department of Urology, The First Affiliated Hospital of Shandong First Medical University, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250014, PR China
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  • Yang Sun
    Affiliations
    Department of Dermatology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, PR China
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Published:November 14, 2022DOI:https://doi.org/10.1016/j.ejca.2022.10.009
      In a recently published article in the European Journal of Cancer, Jiaoyun Lv et al. reported that immunoglobins were expressed in clinical tissues and cell lines derived from glioma and associated with a poor prognosis. Moreover, this study illustrated how immunoglobins from glioma promote malignant proliferation and migration through the HGF/SF-Met or FAK/Src pathway in vitro and in vivo [
      • Lv J.
      • Chen S.
      • Chen X.
      • Xie J.
      • He Z.
      • Fan T.
      • et al.
      Effect of glioma-derived immunoglobulin on biological function of glioma cells.
      ]. The immunoglobins are widely distributed in the blood, tissue fluid, and exocrine fluid, primarily maintaining humoral immunity by binding to the exogenous antigen. In keeping with that notion, classical immunology theory considered B cells the primary source of immunoglobin in circulation. Since the heavy chains of immunoglobins were detected in cancer cell lines, increasing evidence has demonstrated that solid cancer and benign hyperplasia tissues, in addition to lymphoma, could also express and secrete immunoglobins [
      • Kimoto Y.
      Expression of heavy-chain constant region of immunoglobulin and T-cell receptor gene transcripts in human non-hematopoietic tumor cell lines.
      ,
      • Li M.
      • Feng D.Y.
      • Ren W.
      • Zheng L.
      • Zheng H.
      • Tang M.
      • et al.
      Expression of immunoglobulin kappa light chain constant region in abnormal human cervical epithelial cells.
      ,
      • Niu N.
      • Zhang J.
      • Huang T.
      • Sun Y.
      • Chen Z.
      • Yi W.
      • et al.
      IgG expression in human colorectal cancer and its relationship to cancer cell behaviors.
      ]. However, the molecular and biological role of tumor-derived immunoglobins remains largely unknown.

      Abbreviations:

      PTMs (Post-translational modifications), ADCP (Antibody-dependent cellular phagocytic), CNVs (Copy number variations), TCGA (The Cancer Genome Atlas), GBM (Glioblastoma Multiforme), UMAP (Uniform Manifold Approximation and Projection)
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      Linked Article

      • Effect of glioma-derived immunoglobulin on biological function of glioma cells
        European Journal of CancerVol. 175
        • Preview
          Glioma is the most common and most invasive primary central nervous system tumour, and it is urgent to develop new specific therapeutic targets. Studies have confirmed that epithelial-derived tumour cells promote tumour cell proliferation and metastasis by secreting a large number of immunoglobulins (Igs), but the role of tumour-derived Igs in glioma has never been reported.
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