In a recently published article in the European Journal of Cancer, Jiaoyun Lv et al. reported that immunoglobins were expressed in clinical tissues and cell lines derived
from glioma and associated with a poor prognosis. Moreover, this study illustrated
how immunoglobins from glioma promote malignant proliferation and migration through
the HGF/SF-Met or FAK/Src pathway in vitro and in vivo [
[1]
]. The immunoglobins are widely distributed in the blood, tissue fluid, and exocrine
fluid, primarily maintaining humoral immunity by binding to the exogenous antigen.
In keeping with that notion, classical immunology theory considered B cells the primary
source of immunoglobin in circulation. Since the heavy chains of immunoglobins were
detected in cancer cell lines, increasing evidence has demonstrated that solid cancer
and benign hyperplasia tissues, in addition to lymphoma, could also express and secrete
immunoglobins [
2
,
3
,
4
]. However, the molecular and biological role of tumor-derived immunoglobins remains
largely unknown.Abbreviations:
PTMs (Post-translational modifications), ADCP (Antibody-dependent cellular phagocytic), CNVs (Copy number variations), TCGA (The Cancer Genome Atlas), GBM (Glioblastoma Multiforme), UMAP (Uniform Manifold Approximation and Projection)To read this article in full you will need to make a payment
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References
- Effect of glioma-derived immunoglobulin on biological function of glioma cells.Eur J Cancer. 2022; 175: 86-98
- Expression of heavy-chain constant region of immunoglobulin and T-cell receptor gene transcripts in human non-hematopoietic tumor cell lines.Genes Chromosomes Cancer. 1998; 22: 83-86
- Expression of immunoglobulin kappa light chain constant region in abnormal human cervical epithelial cells.Int J Biochem Cell Biol. 2004; 36: 2250-2257
- IgG expression in human colorectal cancer and its relationship to cancer cell behaviors.PLoS One. 2012; 7e47362
- IL35-Producing B cells promote the development of pancreatic neoplasia.Cancer Discov. 2016; 6: 247-255
- Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity.Nature. 2017; 551: 340-345
- O- and N-glycosylation of serum immunoglobulin A is associated with IgA nephropathy and glomerular function.J Am Soc Nephrol. 2021; 32: 2455-2465
- Tissues: the unexplored frontier of antibody mediated immunity.Curr Opin Virol. 2021; 47: 52-67
- Tumor-reactive antibodies evolve from non-binding and autoreactive precursors.Cell. 2022; 185: 1208-1222 e21
- Functional diversification of IgGs through Fc glycosylation.J Clin Invest. 2019; 129: 3492-3498
Article info
Publication history
Published online: November 14, 2022
Accepted:
October 10,
2022
Received:
October 8,
2022
Identification
Copyright
© 2022 Elsevier Ltd. All rights reserved.
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- Effect of glioma-derived immunoglobulin on biological function of glioma cellsEuropean Journal of CancerVol. 175
- PreviewGlioma is the most common and most invasive primary central nervous system tumour, and it is urgent to develop new specific therapeutic targets. Studies have confirmed that epithelial-derived tumour cells promote tumour cell proliferation and metastasis by secreting a large number of immunoglobulins (Igs), but the role of tumour-derived Igs in glioma has never been reported.
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