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Editorial| Volume 177, P194-196, December 01, 2022

Immune checkpoint inhibitor-associated myocarditis and coronary artery disease: There may be more than meets the eye!

  • Alexandre T.J. Maria
    Affiliations
    Internal Medicine & Immuno-Oncology (MedI2O), Institute for Regenerative Medicine and Biotherapy (IRMB), Saint Eloi Hospital, Montpellier University Hospital, Montpellier, France
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  • Clement Delmas
    Affiliations
    Cardiology Department INI-CRT PhyMedExp INSERM CNRS CHU de Montpellier Université de Montpellier France, France
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  • Cyrille Coustal
    Affiliations
    Department of Internal Medicine, Multi-Organic Diseases, Local Referral Center for Rare Auto-immune Diseases, Montpellier University Hospital, Montpellier, France
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  • Pascale Palassin
    Affiliations
    Regional Pharmacovigilance Centre, Department of Medical Pharmacology and Toxicology, Montpellier University Hospital, Montpellier, France
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  • François Roubille
    Correspondence
    Corresponding author: Intensive Cardiac Care Unit, Cardiology Department, Montpellier, France; PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR 9214. 34295 Montpellier cedex 5, France.
    Affiliations
    Cardiology Department INI-CRT PhyMedExp INSERM CNRS CHU de Montpellier Université de Montpellier France, France
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Published:October 28, 2022DOI:https://doi.org/10.1016/j.ejca.2022.09.028
Immune checkpoint inhibitor-associated myocarditis and coronary artery disease: There may be more than meets the eye!
Next ArticleIntelligent multi-modal shear wave elastography to reduce unnecessary biopsies in breast cancer diagnosis (INSPiRED 002): a retrospective, international, multicentre analysis
      The Immune checkpoint blockers (ICB) have greatly improved clinical outcomes in multiple cancer types and are increasingly being used in earlier disease settings alone or in combination with other therapies. However, rare but life-threatening complications defined as immune-related adverse events (irAE) as ICI-induced myocarditis can occur, justifying close monitoring and specific management [
      • Moslehi J.J.
      • Salem J.E.
      • Sosman J.A.
      • Lebrun-Vignes B.
      • Johnson D.B.
      Increased reporting of fatal immune checkpoint inhibitor-associated myocarditis.
      Lancet. 2018; 391: 933
      ,
      • Moslehi J.J.
      • Johnson D.B.
      • Sosman J.A.
      Myocarditis with immune checkpoint blockade.
      N Engl J Med. 2017; 376: 292
      ].

      Keywords

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      References

        • Moslehi J.J.
        • Salem J.E.
        • Sosman J.A.
        • Lebrun-Vignes B.
        • Johnson D.B.
        Increased reporting of fatal immune checkpoint inhibitor-associated myocarditis.
        Lancet. 2018; 391: 933
        View in Article
        • Moslehi J.J.
        • Johnson D.B.
        • Sosman J.A.
        Myocarditis with immune checkpoint blockade.
        N Engl J Med. 2017; 376: 292
        View in Article
        • Drobni Z.D.
        • Alvi R.M.
        • Taron J.
        • Zafar A.
        • Murphy S.P.
        • Rambarat P.K.
        • et al.
        Association between immune checkpoint inhibitors with cardiovascular events and atherosclerotic plaque.
        Circulation. 2020; 142: 2299-2311
        View in Article
        • Lyon A.R.
        • López-Fernández T.
        • Couch L.S.
        • Asteggiano R.
        • Aznar M.C.
        • Bergler-Klein J.
        • et al.
        2022 ESC guidelines on cardio-oncology developed in collaboration with the European hematology association (EHA), the European Society for therapeutic radiology and oncology (ESTRO) and the international cardio-oncology Society (IC-OS) -.
        Eur Heart J. 2022 Aug 26; ehac244
        View in Article
        • Lehmann L.H.
        • Cautela J.
        • Palaskas N.
        • Baik A.H.
        • Meijers W.C.
        • Allenbach Y.
        • et al.
        Clinical strategy for the diagnosis and treatment of immune checkpoint inhibitor-associated myocarditis: a narrative review.
        JAMA Cardiol. 2021; 6: 1329-1337
        View in Article
        • Bonaca M.P.
        • Olenchock B.A.
        • Salem J.E.
        • Wiviott S.D.
        • Ederhy S.
        • Cohen A.
        • et al.
        Myocarditis in the setting of cancer therapeutics: proposed case definitions for emerging clinical syndromes in cardio-oncology.
        Circulation. 2019; 140: 80-91
        View in Article
        • Herrmann J.
        • Lenihan D.
        • Armenian S.
        • Barac A.
        • Blaes A.
        • Cardinale D.
        • et al.
        Defining cardiovascular toxicities of cancer therapies: an International Cardio-Oncology Society (IC-OS) consensus statement.
        Eur Heart J. 2022; 43: 280-299
        View in Article
        • Nowatzke J.
        • Guedeney P.
        • Palaskas N.
        • Lehmann L.
        • Ederhy S.
        • Zhu H.
        • et al.
        Coronary artery disease and revascularization associated with immune checkpoint blocker myocarditis: report from an international registry.
        Eur J Cancer. 2022; S0959–8049: 443-449
        View in Article

      9. Palassin P, Faillie JL, Coustal C, Quantin X, Topart D, Roubille F, et al. Under-reporting of major cardiac adverse events with immune checkpoint inhibitors in clinical trials: importance of post-marketing pharmacovigilance surveys. J Clin Oncol. Accepted for publication Sept 2022.

        View in Article
        • Ferreira V.M.
        • Schulz-Menger J.
        • Holmvang G.
        • Kramer C.M.
        • Carbone I.
        • Sechtem U.
        • et al.
        Cardiovascular magnetic resonance in nonischemic myocardial inflammation: expert recommendations.
        J Am Coll Cardiol. 18 déc 2018; 72: 3158-3176
        View in Article
        • Collet J.P.
        • Thiele H.
        • Barbato E.
        • Barthélémy O.
        • Bauersachs J.
        • Bhatt D.L.
        • et al.
        2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation.
        Eur Heart J. 2021 Apr 7; 42: 1289-1367
        View in Article
        • Nguyễn T.
        • Maria A.T.J.
        • Ladhari C.
        • Palassin P.
        • Quantin X.
        • Lesage C.
        • et al.
        Rheumatic disorders associated with immune checkpoint inhibitors: what about myositis? An analysis of the WHO's adverse drug reactions database.
        Ann Rheum Dis. 2022; 81: e32
        View in Article

      Article Info

      Publication History

      Published online: October 28, 2022
      Accepted: September 24, 2022
      Received: September 5, 2022

      Identification

      DOI: https://doi.org/10.1016/j.ejca.2022.09.028

      Copyright

      © 2022 Elsevier Ltd. All rights reserved.

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