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Ichthyosis associated with immune checkpoint blockade therapy: A novel cutaneous immune-related toxicity

Published:August 15, 2022DOI:https://doi.org/10.1016/j.ejca.2022.07.007
      Immune checkpoint blockers (ICBs) have been associated with a variety of dermatologic adverse reactions. Macular rashes, eczematous and lichenoid reactions, vitiligo, psoriasis and pruritus are some of the most frequently observed and well-known cutaneous toxicities.
      • Sibaud V.
      Dermatologic reactions to immune checkpoint inhibitors: skin toxicities and immunotherapy.
      However, skin reactions derived from ICBs have a wide clinical spectrum, leading to a variety of clinical entities. Therefore, clinicians need to be watchful when they encounter skin reactions. We present the first cases of ichthyosis triggered by ICBs, and we describe the clinical characteristics, the therapeutic interventions, and treatment outcomes of this unusual ICB-induced toxicity.
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