Camastra et al. [
[1]
] reported cardiac magnetic resonance imaging (CMR) of takotsubo cardiomyopathy–like
myocardial dysfunction associated with checkpoint-targeted immunotherapy and the usefulness
of CMR mapping in diagnosis. Non-invasive imaging modalities circumvent the need for
patients with cancer to undergo invasive examinations. Accordingly, we used CMR mapping
to diagnose an axitinib-related cardiac dysfunction. Axitinib, a tyrosine kinase inhibitor
(TKI), is a potent and selective inhibitor of vascular endothelial growth factor receptors.
Hypertension is a common cardiovascular complication, although cardiac dysfunction
is rare. Therefore, we report a case of cardiac dysfunction that occurred after axitinib
resumption despite the patient's history of long-term axitinib treatment without prior
adverse effects. In this case, there were no symptoms or elevated myocardial enzymes,
and a slight electrocardiogram (ECG) abnormality triggered the diagnosis, which was
made based on echocardiography and CMR.To read this article in full you will need to make a payment
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References
- Cardiac magnetic resonance imaging of transient myocardial dysfunction in a patient treated with checkpoint-targeted immunotherapy.Eur J Canc. 2021; 144: 389-391
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Article info
Publication history
Published online: June 11, 2021
Accepted:
May 5,
2021
Received:
April 21,
2021
Identification
Copyright
© 2021 Elsevier Ltd. All rights reserved.
