Camastra et al. [
] reported cardiac magnetic resonance imaging (CMR) of takotsubo cardiomyopathy–like myocardial dysfunction associated with checkpoint-targeted immunotherapy and the usefulness of CMR mapping in diagnosis. Non-invasive imaging modalities circumvent the need for patients with cancer to undergo invasive examinations. Accordingly, we used CMR mapping to diagnose an axitinib-related cardiac dysfunction. Axitinib, a tyrosine kinase inhibitor (TKI), is a potent and selective inhibitor of vascular endothelial growth factor receptors. Hypertension is a common cardiovascular complication, although cardiac dysfunction is rare. Therefore, we report a case of cardiac dysfunction that occurred after axitinib resumption despite the patient's history of long-term axitinib treatment without prior adverse effects. In this case, there were no symptoms or elevated myocardial enzymes, and a slight electrocardiogram (ECG) abnormality triggered the diagnosis, which was made based on echocardiography and CMR.
- Camastra G.
- Arcari L.
- Ciolina F.
- Danti M.
- Cacciotti L.
Cardiac magnetic resonance imaging of transient myocardial dysfunction in a patient treated with checkpoint-targeted immunotherapy.
Eur J Canc. 2021; 144: 389-391
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Published online: June 11, 2021
Accepted: May 5, 2021
Received: April 21, 2021
© 2021 Elsevier Ltd. All rights reserved.