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Corrigendum| Volume 148, P451-452, May 2021

Corrigendum to “Leuprorelin combined with letrozole with/without everolimus in ovarian-suppressed premenopausal women with hormone receptor-positive, HER2-negative metastatic breast cancer: The LEO studyˮ [Eur J Canc 144 (2021) 341–350]

Published:March 07, 2021DOI:https://doi.org/10.1016/j.ejca.2021.02.004
      The authors regret that the numbers of bone metastasis in this LEO trial (Table 1) need to be corrected as follows:
      Table 1Patient characteristics.
      CharacteristicsEVE arm (n = 92)LET arm (n = 45)
      Age, years, median (range)44 (24–54)45 (25–56)
      ECOG performance status
       049 (53.3)22 (48.9)
       142 (45.7)23 (51.1)
       21 (1.1)0
      Visceral disease56 (60.9)27 (60.0)
      Bone only disease5 (5.4)6 (13.3)
      Previous sensitivity to endocrine therapy
      Endocrine therapy is considered sensitive if outside of primary endocrine resistance.
      (%)
      68 (73.9)34 (75.6)
      Previous endocrine therapy
       Tamoxifen54 (58.7)26 (57.8)
       Tamoxifen → GnRH agonist18 (19.6)9 (20.2)
       Tamoxifen + GnRH agonist20 (21.7)10 (22.2)
      Previous chemotherapy15 (16.3)6 (13.3)
      Measurable disease83 (90.2)39 (86.7)
      Number of metastatic sites
       126 (28.3)15 (33.3)
       229 (31.5)14 (31.1)
       ≥337 (40.2)16 (35.6)
      Site of metastasis
       Lung29 (31.5)18 (40.0)
       Liver25 (27.2)12 (26.7)
       Bone66 (71.7)32 (71.1)
      Purpose of the most recent treatment
       Adjuvant therapy45 (48.9)26 (57.8)
       Palliative therapy47 (51.1)19 (42.2)
      Line of treatment
       1st line45 (48.9)26 (57.8)
       2nd line31 (33.7)13 (28.9)
       ≥3rd line16 (17.4)6 (13.3)
      EVE, everolimus; LET, letrozole; LEUP, leuprorelin; ECOG, Eastern Cooperative Oncology Group; GnRH, gonadotropin-releasing hormone.
      Endocrine therapy is considered sensitive if outside of primary endocrine resistance.
      Bone meta 59 (64.1)--> 66 (71.7)in the EVE arm.
      27 (60.0)--> 31 (71.1) in the LET arm.
      Please find the correct Table 1 below. These corrections do not affect any description in the published article.
      The authors would like to apologise for any inconvenience caused.

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