Editorial| Volume 148, P430-431, May 2021

Editorial for Cribriform architecture prostatic adenocarcinoma in needle biopsy is a strong independent predictor for lymph node metastases in radical prostatectomy (M. Downes et al.) and Ductal variant prostate carcinoma is associated with a significantly shorter metastasis-free survival (K. Chow et al.)

Published:February 19, 2021DOI:
      In this volume of the European Journal of Cancer, two complementary studies regarding the histopathology of Gleason grade IV (GG4) prostate cancer (PCa) are presented. Herein, the authors explore specific histopathological aspects of GG4 PCa predictive of poor outcome and lymph node status. The common message underlined by both reports is that features accessible via routine histology of prostate biopsy or prostatectomy specimens yield valuable information regarding both patient outcome and specific molecular changes.
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        • Rubin M.A.
        • de La Taille A.
        • Bagiella E.
        • Olsson C.A.
        • O'Toole K.M.
        Cribriform carcinoma of the prostate and cribriform prostatic intraepithelial neoplasia: incidence and clinical implications.
        Am J Surg Pathol. juill 1998; 22: 840-848
        • Humphrey P.A.
        • Moch H.
        • Cubilla A.L.
        • Ulbright T.M.
        • Reuter V.E.
        The 2016 WHO classification of tumours of the urinary system and male genital organs-Part B: prostate and bladder tumours.
        Eur Urol. 2016; 70: 106-119
        • Epstein J.I.
        • Amin M.B.
        • Fine S.W.
        • Algaba F.
        • Aron M.
        • Baydar D.E.
        • et al.
        The 2019 genitourinary pathology society (GUPS) white paper on contemporary grading of prostate cancer.
        Arch Pathol Lab Med. juin 2020; 26
        • Dong F.
        • Yang P.
        • Wang C.
        • Wu S.
        • Xiao Y.
        • McDougal W.S.
        • et al.
        Architectural heterogeneity and cribriform pattern predict adverse clinical outcome for Gleason grade 4 prostatic adenocarcinoma.
        Am J Surg Pathol. déc 2013; 37: 1855-1861
        • Elfandy H.
        • Armenia J.
        • Pederzoli F.
        • Pullman E.
        • Pertega-Gomes N.
        • Schultz N.
        • et al.
        Genetic and epigenetic determinants of aggressiveness in cribriform carcinoma of the prostate.
        Mol Cancer Res. févr 2019; 17: 446-456
        • Trudel D.
        • Downes M.R.
        • Sykes J.
        • Kron K.J.
        • Trachtenberg J.
        • van der Kwast T.H.
        Prognostic impact of intraductal carcinoma and large cribriform carcinoma architecture after prostatectomy in a contemporary cohort.
        Eur J Cancer. juin 2014; 50: 1610-1616
        • Shah R.B.
        • Yoon J.
        • Liu G.
        • Tian W.
        Atypical intraductal proliferation and intraductal carcinoma of the prostate on core needle biopsy: a comparative clinicopathological and molecular study with a proposal to expand the morphological spectrum of intraductal carcinoma.
        Histopathology. nov 2017; 71: 693-702
        • van Leenders G.J.L.H.
        • van der Kwast T.H.
        • Grignon D.J.
        • Evans A.J.
        • Kristiansen G.
        • Kweldam C.F.
        • et al.
        The 2019 international society of urological pathology (ISUP) consensus conference on grading of prostatic carcinoma.
        Am J Surg Pathol. août 2020; 44: e87-99

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