We were very impressed by the interesting and intriguing work of van der Doelen et al. [
[1]
] recently published in your Journal . This inspires some considerations that we would
gladly share with the scientific community.Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to European Journal of CancerAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Impact of DNA damage repair defects on response to radium-223 and overall survival in metastatic castration-resistant prostate cancer.Eur J Canc. 2020; 136 (Oxford, England : 1990): 16-24https://doi.org/10.1016/j.ejca.2020.05.001
- Overall survival in men with bone metastases from castration-resistant prostate cancer treated with bone-targeting radioisotopes: a meta-analysis of individual patient data from randomized clinical trials.JAMA Oncol. 2020; 6: 206-216https://doi.org/10.1001/jamaoncol.2019.4097
- Reversibility of castration resistance status after Radium-223 dichloride treatment: clinical evidence and Review of the literature.Int J Radiat Biol. 2018; : 1-29https://doi.org/10.1080/09553002.2019.1558301
- An agent-based model of prostate Cancer bone metastasis progression and response to Radium223.BMC Canc. 2020; 20: 605https://doi.org/10.1186/s12885-020-07084-w
- Germline DNA-repair gene mutations and outcomes in men with metastatic castration-resistant prostate cancer receiving first-line abiraterone and enzalutamide.Eur Urol. 2018; 74: 218-225https://doi.org/10.1016/j.eururo.2018.01.035
- Efficacy of radium-223 in bone-metastatic castration-resistant prostate cancer with and without homologous repair gene defects.Eur Urol. 2019; 76: 170-176https://doi.org/10.1016/j.eururo.2018.09.040
- Prostate-specific antigen flare phenomenon during 223Ra-dichloride treatment for bone metastatic castration-resistant prostate cancer: a case report.Clin Genitourin Canc. 2016; 14: e529-e533https://doi.org/10.1016/j.clgc.2016.04.014
- Radium-223 in combination with docetaxel in patients with castration-resistant prostate cancer and bone metastases: a phase 1 dose escalation/randomised phase 2a trial.Eur J Canc. 2019; 114 (Oxford, England : 1990): 107-116https://doi.org/10.1016/j.ejca.2019.04.007
- Primary radical prostatectomy or ablative radiotherapy as protective factors for patients with mCRPC treated with radium-223 dichloride: an Italian multicenter study.Clin Genitourin Canc. 2020; 18: 185-191https://doi.org/10.1016/j.clgc.2019.10.009
- Validation of the 3-variable prognostic score (3-PS) in mCRPC patients treated with (223)Radium-dichloride: a national multicenter study.Ann Nucl Med. 2020; https://doi.org/10.1007/s12149-020-01501-7
Article info
Publication history
Published online: December 03, 2020
Accepted:
September 26,
2020
Received in revised form:
September 17,
2020
Received:
August 13,
2020
Identification
Copyright
© 2020 Elsevier Ltd. All rights reserved.
ScienceDirect
Access this article on ScienceDirectLinked Article
- Impact of DNA damage repair defects on response to radium-223 and overall survival in metastatic castration-resistant prostate cancerEuropean Journal of CancerVol. 136
- PreviewRadium-223 is a targeted alpha radiation therapy for metastatic castration-resistant prostate cancer. DNA damage repair (DDR) defective prostate cancers, specifically genetic aberrations leading to homologous recombination deficiency (HRD), accumulate irreparable DNA damage following genotoxic treatment. This retrospective study assessed DDR mutation status in patients treated with radium-223, investigating their association with efficacy and overall survival (OS).
- Full-Text
- Preview
- Response to comment on “Impact of DNA damage repair defects on response to radium-223 and overall survival in metastatic castration-resistant prostate cancer”European Journal of CancerVol. 144