The risk of cardiovascular disease in irradiated breast cancer patients: The role of cardiac calcifications and adjuvant treatment

      Background: (Neo) adjuvant treatments including anthracyclines, trastuzumab and (left-sided) radiotherapy (RT) are associated with an increased risk of cardiovascular disease (CVD). Breast cancer patients with pre-existing CVD risk factors have the highest risk of treatment induced cardiotoxicity. Coronary artery calcium (CAC) is a strong independent CVD risk factor and can be quantified on dedicated radiotherapy planning CT scans of the chest. Automated assessment of CAC scores in breast cancer patients planned for RT may be helpful in detecting patients at increased CVD risk. In the Bragatston study, we evaluate the association between automated CAC measurement on RT planning CT scans and the risk of CVD in breast cancer patients treated with RT.
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