- •Data are limited on patients with autoimmune disease (AID) receiving immunotherapy.
- •SAUL evaluated atezolizumab in a broad population with urinary tract carcinoma.
- •Subgroup analyses of 35 atezolizumab-treated patients with AID were prespecified.
- •Treatment-related adverse events were manageable.
- •Treating AID patients with atezolizumab requires caution, but AID is not a barrier.
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to European Journal of Cancer
- Cancer immunotherapy: opportunities and challenges in the rapidly evolving clinical landscape.Eur J Cancer. 2017; 81: 116-129https://doi.org/10.1016/j.ejca.2017.01.035
- Immunotherapy for urothelial carcinoma: current evidence and future directions.Curr Urol Rep. 2018; 19: 109https://doi.org/10.1007/s11934-018-0851-7
- MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer.Nature. 2014; 515: 558-562https://doi.org/10.1038/nature13904
- Atezolizumab (MPDL3280A) monotherapy for patients with metastatic urothelial cancer: long-term outcomes from a phase 1 study.JAMA Oncol. 2018; 4: 537-544https://doi.org/10.1001/jamaoncol.2017.5440
Genentech, Inc. Tecentriq Prescribing Information. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/761034s010lbl.pdf. [Accessed 6 April 2020].
Roche Registration GmbH. Tecentriq summary of Product characteristics. https://www.ema.europa.eu/en/documents/product-information/tecentriq-epar-product-information_en.pdf. [Accessed 6 April 2020].
- Autoimmunity and cancer, the paradox comorbidities challenging therapy in the context of preexisting autoimmunity.J Interferon Cytokine Res. 2019; 39: 72-84https://doi.org/10.1089/jir.2018.0060
- Urinary bladder cancer in Wegener's granulomatosis: risks and relation to cyclophosphamide.Ann Rheum Dis. 2004; 63: 1307-1311
- Cancer and autoimmune diseases.Autoimmun Rev. 2017; 16: 1049-1057https://doi.org/10.1016/j.autrev.2017.07.022
- Malignancies in Wegener's granulomatosis: incidence and relation to cyclophosphamide therapy in a cohort of 293 patients.J Rheumatol. 2008; 35: 100-105
- Prolonged risk of specific malignancies following cyclophosphamide therapy among patients with granulomatosis with polyangiitis.Rheumatology (Oxford). 2015; 54: 1345-1350https://doi.org/10.1093/rheumatology/keu372
- Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial.Lancet. 2016; 387: 1909-1920https://doi.org/10.1016/S0140-6736(16)00561-4
- Atezolizumab versus chemotherapy in patients with platinum-treated locally advanced or metastatic urothelial carcinoma (IMvigor211): a multicentre, open-label, phase 3 randomised controlled trial.Lancet. 2018; 391: 748-757https://doi.org/10.1016/S0140-6736(17)33297-X
- Safety and efficacy of immune checkpoint inhibitors in patients with cancer and preexisting autoimmune disease: a nationwide, multicenter cohort study.Arthritis Rheumatol. 2019; 71: 2100-2111https://doi.org/10.1002/art.41068
- Preexisting autoimmune disease: implications for immune checkpoint inhibitor therapy in solid tumors.J Natl Compr Canc Netw. 2019; 17: 750-757https://doi.org/10.6004/jnccn.2019.7310
- Safety and efficacy of anti-programmed death 1 antibodies in patients with cancer and pre-existing autoimmune or inflammatory disease.Eur J Cancer. 2018; 91: 21-29https://doi.org/10.1016/j.ejca.2017.12.008
- Cancer immunotherapy in patients with preexisting autoimmune disorders.Semin Immunopathol. 2017; 39: 333-337https://doi.org/10.1007/s00281-016-0595-8
- Immune checkpoint inhibitors may be safe for patients with preexisting autoimmune disease.CA Cancer J Clin. 2020; 70: 3-4https://doi.org/10.3322/caac.21587
- Autoimmune diseases and immune-checkpoint inhibitors for cancer therapy: review of the literature and personalized risk-based prevention strategy.Ann Oncol. 2020; (S0923-7534(20)36364-X)https://doi.org/10.1016/j.annonc.2020.03.285
- Primary results from SAUL, a multinational single-arm safety study of atezolizumab therapy for locally advanced or metastatic urothelial or nonurothelial carcinoma of the urinary tract.Eur Urol. 2019; 76: 73-81https://doi.org/10.1016/j.eururo.2019.03.015
- Use of immune checkpoint inhibitors in the treatment of patients with cancer and preexisting autoimmune disease: a systematic review.Ann Intern Med. 2018; 168: 121-130https://doi.org/10.7326/M17-2073
- Risk of toxicity after initiating immune checkpoint inhibitor treatment in patients with rheumatoid arthritis.J Clin Rheumatol. 2020 Jan 22; ([Epub ahead of print])https://doi.org/10.1097/RHU.0000000000001314
- Safety of programmed death-1 pathway inhibitors among patients with non-small-cell lung cancer and preexisting autoimmune disorders.J Clin Oncol. 2018; 36: 1905-1912https://doi.org/10.1200/JCO.2017.77.0305
- Real-world outcomes of underrepresented patient populations treated with immune checkpoint inhibitors (ICIs): African American descent, poor ECOG performance status, and chronic viral infections.J Clin Oncol. 2019; 37 (abstract 2587)
- Clinical practice guidelines in Oncology (NCCN Guidelines®) management of immunotherapy-related toxicities.(Version 1.2020 — December 16)https://www.nccn.org/professionals/physician_gls/pdf/immunotherapy.pdfDate: 2019Date accessed: March 5, 2020
- Immune checkpoint inhibitor therapy in patients with preexisting inflammatory bowel disease.J Clin Oncol. 2020; 38: 576-583https://doi.org/10.1200/JCO.19.01674
☆Sources of support: The SAUL study and medical writing for this publication were funded by F Hoffmann-La Roche Ltd, Basel, Switzerland.