Editorial| Volume 131, P51-52, May 2020

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Chimeric antigen receptor (CAR) T-cells on the march: from diffuse large B-cell lymphoma to mantle cell lymphoma

Published:April 10, 2020DOI:
      Mantle cell lymphoma (MCL) is an aggressive disease which is considered incurable with conventional therapy. Novel agents approved in this indication include bortezomib, lenalidomide and bruton tyrosine kinase (BTK) inhibitors (ibrutinib, acalabrutinib and zanubrutinib). However, for many patients, the durability of response with these drugs is limited [
      • Cheah C.Y.
      • Seymour J.F.
      • Wang M.L.
      Mantle cell lymphoma.
      ]. Thus, new therapies are needed.
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