Common cutaneous events, such as lichenoid reactions and vitiligo, induced by immune
checkpoint inhibitors (ICs) are typically of low grade, while toxic epidermal necrolysis
(TEN) as an immune-related adverse event (irAE) is quite rare. However, gene expression
profile of lesional skin from anti–programmed cell death-1 (PD-1)–related cutaneous
AEs resembled Stevens-Johnson syndrome (SJS)/TEN-like pattern [
[1]
], suggesting that anti–PD-1 antibody could induce SJS/TEN-like reactions at least
in some patients and it should be considered during treatment with ICs. Despite the
increase in usage, predictive markers for disease progression to severe irAEs remain
unelucidated. We encountered a case of TEN concomitant with other irAEs developed
after several months of nivolumab therapy. To understand the cytokine profile and
immune regulation in our case, the cytokine levels and the state of regulatory T cells
(Tregs) were analysed during the clinical course.To read this article in full you will need to make a payment
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Article info
Publication history
Published online: April 02, 2020
Accepted:
February 13,
2020
Received:
January 6,
2020
Identification
Copyright
© 2020 Elsevier Ltd. All rights reserved.
