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Letter to the Editor| Volume 131, P37-39, May 2020

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Successful management of refractory immune-mediated enterocolitis with cyclosporine

Published:April 08, 2020DOI:https://doi.org/10.1016/j.ejca.2020.02.014
      Immune checkpoint blockade with antibodies against programmed cell death 1 (PD-1) receptor and cytotoxic T lymphocyte antigen 4 (CTLA-4) has become a new game changer in the treatment of cancer, showing unprecedented clinical efficacy. As a result of excessive immunity against healthy organs, the use of these drugs is associated with a wide spectrum of immune-related adverse events (irAEs), such as enterocolitis [
      • Hsieh A.H.-C.
      • Ferman M.
      • Brown M.P.
      • Andrews J.M.
      Vedolizumab: a novel treatment for ipilimumab-induced colitis.
      ,
      • Soularue E.
      • Lepage P.
      • Colombel J.F.
      • Coutzac C.
      • Faleck D.
      • Marthey L.
      • et al.
      Enterocolitis due to immune checkpoint inhibitors: a systematic review.
      ].
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