We write in reply to the comprehensive and insightful letter from Dr Pashankar and
Dr Frazier regarding our article, ‘A multicentre retrospective cohort study of ovarian
germ cell tumours: Evidence for chemotherapy de-escalation and alignment of paediatric
and adult practice’[
[1]
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References
- A multicentre retrospective cohort study of ovarian germ cell tumours: Evidence for chemotherapy de-escalation and alignment of paediatric and adult practice.Eur J Canc. 2019; 113: 19-27
- Is adjuvant chemotherapy indicated in ovarian immature teratomas? A combined data analysis from the Malignant Germ Cell Tumor International Collaborative.Cancer. 2016; 122: 230-237
- Immature (malignant) teratoma of the ovary: a clinical and pathologic study of 58 cases.Cancer. 1976; 37: 2359-2372
- Non-epithelial ovarian cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.Ann Oncol. 2018; 29: iv1-iv18
- Ovarian cancer including fallopian tube cancer and primary peritoneal cancer.in: 2017. National Comprehensive Cancer Network, 2017 November 9 (Version 4.2017 ed)
- Surgical resection alone is effective treatment for ovarian immature teratoma in children and adolescents: a report of the pediatric oncology group and the children’s cancer group.Am J Obstet Gynecol. 1999; 181: 353-358
Article info
Publication history
Published online: March 18, 2020
Accepted:
February 4,
2020
Received:
January 30,
2020
Identification
Copyright
© 2020 Elsevier Ltd. All rights reserved.
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Access this article on ScienceDirectLinked Article
- A multicentre retrospective cohort study of ovarian germ cell tumours: Evidence for chemotherapy de-escalation and alignment of paediatric and adult practiceEuropean Journal of CancerVol. 113
- PreviewAdult guidelines recommend BEP (bleomycin, etoposide, cisplatin) for all ovarian germ cell tumours, causing debilitating toxicities in young patients who will survive long term. Paediatricians successfully reduce toxicities by using lower bleomycin doses and substituting carboplatin for cisplatin, while testicular and paediatric immature teratomas (ITs) are safely managed with surgery alone.
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- Re: A multicentre retrospective cohort study of ovarian germ cell tumours: Evidence for chemotherapy de-escalation and alignment of paediatric and adult practiceEuropean Journal of CancerVol. 130
- PreviewThe article by Newton et al [1], advances the conversation on the role of chemotherapy in ovarian immature teratoma (IT) and is very well written. The authors reviewed 42 patients with ovarian IT, 33 of whom had surgery alone and 9 patients had surgery and chemotherapy. They found that recurrence risk was not reduced by first-line chemotherapy. This is similar to our experience [2] and the experience of others [3].
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