Highlights
- •Patients with Parkinson’s disease (PD) had a lower overall cancer risk than those without PD.
- •Patients with PD showed lower risk of colorectal cancer, gastric cancer, liver cancer, and pancreatic cancer.
- •They also showed lower risk of lung cancer, prostate cancer, laryngeal cancer, leukaemia and uterine cervical cancer.
- •Despite environmental, ethnic and socioeconomic differences, our results were consistent with previous Western studies.
- •Further studies are required to investigate the underlying mechanism of the association between PD and cancer.
Abstract
Introduction
The association between Parkinson’s disease (PD) and cancer development is controversial,
especially in Asia. Therefore, we conducted a nationwide population-based cohort study
to assess the overall cancer risk and risk for specific cancers in patients with PD
in Korea.
Methods
Using data from the Korean National Health Insurance Database, we analysed 52,009
patients diagnosed with PD between 2010 and 2015 and 260,045 individuals without PD.
Patients previously diagnosed with cancer were excluded. The age- and sex-matched
cohorts were followed up until 2016 for cancer development. Cox proportional hazards
regression models were used to evaluate the relationship between PD and cancer.
Results
Patients with PD had a lower overall cancer risk (hazard ratio [HR], 0.78; 95% confidence
interval [CI], 0.74–0.82) after adjustment for multiple covariates during 2,022,852.6
person-years of follow-up. Patients with PD showed significantly lower risk of laryngeal
cancer (HR, 0.45; 95% CI, 0.21–0.84), gastric cancer (HR, 0.72; 95% CI, 0.63–0.82),
colorectal cancer (HR, 0.675; 95% CI, 0.60–0.76), liver cancer (HR, 0.80; 95% CI,
0.67–0.95), pancreatic cancer (HR, 0.75; 95% CI, 0.62–0.91), lung cancer (HR, 0.73;
95% CI, 0.63–0.84), leukaemia (HR, 0.49; 95% CI, 0.24–0.89), uterine cervical cancer
(HR, 0.64; 95% CI, 0.40–0.99) and prostate cancer (HR, 0.78; 95% CI, 0.66–0.91).
Conclusion
This nationwide population-based cohort study revealed that patients with PD had lower
overall cancer risk and lower risk of specific cancers. Contrary to the results of
the recent Asian study, this large cohort study revealed that patients with PD were
less likely to develop cancer than those without PD in Korea. Our results were consistent
with those of previous Western studies, despite differences in ethnicity and environment.
Keywords
Abbreviations:
CI (confidence interval), DM (diabetes mellitus), HR (hazard ratio), ICD-10-CM (International Classification of Diseases), 10th Revision (Clinical Modification), NHIS (National Health Insurance Service), PD (Parkinson’s disease), RIDs (rare intractable diseases)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: June 20, 2019
Accepted:
April 26,
2019
Received in revised form:
April 25,
2019
Received:
January 29,
2019
Identification
Copyright
© 2019 Elsevier Ltd. All rights reserved.
