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Treatment in real-life patients with HER2-positive metastatic breast cancer: What we learn from the KAMILLA trial?

      The advent of anti-HER2 agents dramatically changed the natural history of HER2-positive breast cancer. Strong research efforts have brought, starting with trastuzumab, a class of anti-HER2–targeted therapies, which includes, at present, four approved agents in the metastatic setting: trastuzumab, lapatinib, pertuzumab and trastuzumab emtansine (T-DM1). These agents have led to doubling median overall survival (OS), which is currently longer than 55 months, and more than tripling the 5-year survival rate [
      • Swain S.M.
      • Baselga J.
      • Kim S.B.
      • et al.
      Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer.
      ].

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