Until recently, clinical trials investigating cancer drugs have been conducted separately
for different tumour location and histological types because they were the primary
known determinant of drug efficacy. With the development of therapies targeting genomic
alterations in tumour cells, novel clinical development strategies are necessary.
Indeed, the genomic alteration can be uncommon in one particular tumour type and can
be shared by several tumour types. Basket trials typically include patients with diverse
tumour types sharing one distinguishing feature (i.e. one single or one class of biological
alterations). Patients are then assigned to a drug expected to be active for tumours
that harbour that alteration [
1
,
2
,
3
].Keywords
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Article info
Publication history
Published online: January 14, 2019
Accepted:
December 13,
2018
Received:
November 29,
2018
Identification
Copyright
© 2018 Elsevier Ltd. All rights reserved.
