Highlights
- •The Dutch national multidisciplinary guideline on spinal metastases to improve the quality of care.
- •A summary of the guideline providing an easy-to-use overview for physicians to use in their daily practice.
- •Easy-to-use flowcharts for the diagnostic process and therapy selection in patients with spinal metastases.
Abstract
This article is a summary of the revised Dutch multidisciplinary evidence-based guideline
‘Spinal metastases’ (English translation available at: https://www.oncoline.nl/spinal-metastases) that was published at the end of 2015. This summary provides an easy-to-use overview
for physicians to use in their daily practice.
Keywords
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References
- Alarm symptoms of spinal metastases in patients with cancer.Ned Tijdschr Geneeskd. 2015; 159: A9256
- New Dutch guideline on spinal metastases: extended to include spinal localizations of hematological malignancies.Ned Tijdschr Geneeskd. 2015; 159: A9101
- The Dutch national guideline on metastases and hematological malignancies localized within the spine; a multidisciplinary collaboration towards timely and proactive management.Cancer Treat Rev. 2018; 69: 29-39
- Cancer statistics, 2016.CA Cancer J Clin. 2016 Jan; 66 (3rd ed): 7-30
- The past, present, and future of cancer incidence in the United States: 1975 through 2020.Cancer. 2015 Jun 1; 121: 1827-1837
- Surgery insight: current management of epidural spinal cord compression from metastatic spine disease.Nat Clin Pract Neurol. 2006; 2: 87-94
- Systematic review of the diagnosis and management of malignant extradural spinal cord compression: the Cancer Care Ontario Practice Guidelines Initiative's Neuro-Oncology Disease Site Group.J Clin Oncol. 2005; 23: 2028-2037
- Bone metastases.in: Carsten Nieder C. Langendijk J.A. Re-irradiation: new frontiers. Springer, Berlin2011: 191-204
- A score to identify patients with metastatic spinal cord compression who may be candidates for best supportive care.Cancer. 2013; 119: 897-903
- Prognostic factors associated with survival in patients with symptomatic spinal bone metastases: a retrospective cohort study of 1 043 patients.Neuro Oncol. 2014; 16: 991-998
- Metastatic spinal cord compression. Occurrence, symptoms, clinical presentations and prognosis in 398 patients with spinal cord compression.Acta Neurochir. 1990; 107: 37-43
- Prognostic factors in metastatic spinal cord compression: a prospective study using multivariate analysis of variables influencing survival and gait function in 153 patients.Int J Radiat Oncol Biol Phys. 2000; 46: 1163-1169
- Diagnosis and treatment of spinal cord compression in malignant disease.Cancer Treat Rev. 1993; 19: 129-150
- Spinal cord compression from epidural metastases.N Engl J Med. 1992; 327: 614-619
- Prediction of survival in patients with metastases in the spinal column: results based on a randomized trial of radiotherapy.Cancer. 2005; 103: 320-328
- Back pain in cancer patients; a clinical study with MRI.([thesis]) University of Amsterdam, Amsterdam1996
- Detection of vertebral metastases: comparison between MR imaging and bone scintigraphy.Radiographics. 1991; 11: 219-232
- MRI of bone metastases.Eur Radiol. 1998; 8: 1345-1351
- Detection of osseous metastases of the spine: comparison of high resolution multi-detector-CT with MRI.Eur J Radiol. 2009; 69: 567-573
- Diagnosis of vertebral metastasis, epidural metastasis, and malignant spinal cord compression: are T(1)-weighted sagittal images sufficient?.Magn Reson Imaging. 2000; 18: 819-824
- Reliability analysis of the epidural spinal cord compression scale.J Neurosurg Spine. 2010; 13: 324-328
- A score predicting posttreatment ambulatory status in patients irradiated for metastatic spinal cord compression.Int J Radiat Oncol Biol Phys. 2008; 72: 905-908
- Validation of a score predicting post-treatment ambulatory status after radiotherapy for metastatic spinal cord compression.Int J Radiat Oncol Biol Phys. 2011; 79: 1503-1506
- How effective is a virtual consultation process in facilitating multidisciplinary decision-making for malignant epidural spinal cord compression?.Int J Radiat Oncol. 2012; 2: E167-E172
- How accurate are physicians' clinical predictions of survival and the available prognostic tools in estimating survival times in terminally ill cancer patients? A systematic review.Clin Oncol. 2001; 13: 209-218
- Accuracy of survival prediction by palliative radiation oncologists.IJROBP. 2005; 61: 870-873
- A systematic review of physicians' survival predictions in terminally ill cancer patients.BMJ. 2003; 327: 195-198
- Predictive value of seven preoperative prognostic scoring systems for spinal metastases.Eur Spine J. 2008; 17: 1488-1495
- Predictive value of six prognostic scoring systems for spinal bone metastases: an analysis based on 1379 patients.Spine. 2016; 41: 155-162
- Development of a model with which to predict the life expectancy of patients with spinal epidural metastasis.Cancer. 2007; 110: 2042-2049
- A novel classification system for spinal instability in neoplastic disease: an evidence-based approach and expert consensus from the Spine Oncology Study Group.Spine. 2010; 35: 1221-1229
- Spinal instability neoplastic score: an analysis of reliability and validity from the spine oncology study group.J Clin Oncol. 2011; 29: 3072-3077
- The spine instability neoplastic score: an independent reliability and reproducibility analysis.Spine J. 2014; 14: 1466-1469
- Interobserver agreement for the spine instability neoplastic score varies according to the experience of the evaluator.Clinics. 2013; 68: 213-218
- Reliability of the spinal instability neoplastic score (SINS) among radiation oncologists: an assessment of instability secondary to spinal metastases.Radiat Oncol. 2014; 9: 69
- Vertebral compression fracture after spine stereotactic body radiotherapy: a multi-institutional analysis with a focus on radiation dose and the spinal instability neoplastic score.J Clin Oncol. 2013; 31: 3426-3431
- Vertebral compression fracture (VCF) after spine stereotactic body radiation therapy (SBRT): analysis of predictive factors.Int J Radiat Oncol Biol Phys. 2012; 84: 343-349
- Clinical evaluation of the spinal instability neoplastic score in patients treated with radiotherapy for symptomatic spinal bone metastases.Spine. 2017; 16: E956-E962
- Single fraction radiotherapy is efficacious: a further analysis of the Dutch Bone Metastasis Study controlling for the influence of retreatment.Int J Radiat Oncol Biol Phys. 2004; 59: 528-537
- A systematic overview of radiation therapy effects in skeletal metastases.Acta Oncol. 2003; 42: 620-633
- Effectiveness of radiation therapy without surgery in metastatic spinal cord compression: final results from a prospective trial.Int J Rad Oncol Biol Phys. 1995; 32: 959-967
- Metastatic spinal cord compression: radiotherapy outcome and dose fractionation.Radiother Oncol. 2003; 68: 175-180
- Palliative radiotherapy trials for bone metastases: a systematic review.J Clin Oncol. 2007; 25: 1423-1436
- Short-course versus split-course radiotherapy in metastatic spinal cord compression: results of a phase III, randomized, multicenter trial.J Clin Oncol. 2005; 23: 3358-3365
- 8Gy single-dose radiotherapy is effective in metastatic spinal cord compression: results of a phase III randomized multicentre Italian trial.Radiother Oncol. 2009; 93: 174-179
- Stereotactic body radiotherapy: a critical review for nonradiation oncologists.Cancer. 2014; 120: 942-954
- Spinale metastases: is stereotactic body radiation therapy supported by evidence?.Crit Rev Oncol Hematol. 2016; 98: 147-158
- Evaluation of five radiation schedules and prognostic factors for metastatic spinal cord compression.J Clin Oncol. 2005; 23: 3366-3375
- Preliminary results of spinal cord compression recurrence evaluation (score-1) study comparing short-course versus long-course radiotherapy for local control of malignant epidural spinal cord compression.Int J Radiat Oncol Biol Phys. 2009; 73: 228-234
- Safety and efficacy of percutaneous vertebroplasty in malignancy: a systematic review.Clin Radiol. 2011; 66: 63-72
- Osteoblastic and mixed spinal metastases: evaluation of the analgesic efficacy of percutaneous vertebroplasty.Am J Neuroradiol. 2007; 28: 570-574
- Clinical and radiographic results of balloon kyphoplasty for treatment of vertebral body metastases and multiple myelomas.J Clin Neurosci. 2010; 17: 219-224
- Palliation of compression fractures in cancer patients by vertebral augmentation: a retrospective analysis.J Neurointerv Sur. 2010; 2: 221-228
- Cement augmentation in spinal tumors: a systematic review comparing vertebroplasty and kyphoplasty.Evid Based Spine Care J. 2011; 2: 35-43
- Cement leakage in percutaneous vertebroplasty for osteoporotic vertebral compression fractures: identification of risk factors.Spine. 2011; 11: 839-848
- Cement leakage in percutaneous vertebroplasty for spinal metastases: a retrospective evaluation of incidence and risk factors.Spine. 2014; 39: 332-338
- Image-guided radiofrequency ablation of spinal tumors: preliminary experience with an expandable array electrode.Cancer J. 2002; 8: 33-39
- Treatment of vertebral tumor with posterior wall defect using image-guided radiofrequency ablation combined with vertebroplasty: preliminary results in 12 patients.J Vasc Interv Radiol. 2007; 18: 741-747
- Percutaneous radiofrequency ablation of painful spinal tumors adjacent to the spinal cord with real-time monitoring of spinal canal temperature: a prospective study.Cardiovasc Intervent Radiol. 2009; 32: 70-75
- Survival, complications and outcome in 282 patients operated for neurological deficit due to thoracic or lumbar spinal metastases.Eur Spine J. 2006; 15: 196-202
- Risk factors for survival in 106 surgically treated patients with symptomatic spinal epidural metastasis.Eur Spine J. 2013; 22: 1408-1416
- Reconstruction with expandable cages after single- and multilevel corpectomies for spinal metastases: a prospective case series of 60 patients.Spine J. 2014; 14: 2085-2093
- Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind study.J Clin Oncol. 2010; 28: 5132-5139
- Postoperative stereotactic body radiation therapy (SBRT) for spine metastases: a critical review to guide practice.Int J Radiat Oncol Biol Phys. 2016; 95: 1414-1428
- Stereotactic body radiotherapy for spinal metastases: practice guidelines, outcomes and risks.Cancer J. 2016; 22: 280-289
- Randomized Phase II Trial evaluating pain response in patients with spinal metastases following Stereotactic Body Radiotherapy versus three-dimensional conformal radiotherapy.Radiother Oncol. 2018; 128: 274-282
- Radiotherapy without steroids in selected metastatic spinal cord compression patients. A phase II trial.Am J Clin Oncol. 1996; 19: 179-183
Article info
Publication history
Published online: October 15, 2018
Accepted:
August 29,
2018
Received in revised form:
August 22,
2018
Received:
June 4,
2018
Identification
Copyright
© 2018 Elsevier Ltd. All rights reserved.
