Depletion of MDSC improves the anti-neuroblastoma effect of adoptive recipient leukocyte infusion in allogeneic bone marrow transplanted mice

      Background: High-risk neuroblastoma is the most frequent extra-cranial solid tumor in childhood, and is faced with poor prognosis despite intensive therapy. Allogeneic stem cell transplantation in combination with adoptive recipient leukocyte infusion (RLI) has been proposed as a potentially promising new strategy, and has already been shown to be effective in murine neuroblastoma models.
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