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Mesothelin-targeted bispecific antibodies drive synthetic agonistic receptor – Transduced T cells to mediate specific and conditional therapy of human pancreatic cancer models

      Background: Inadequate delivery of T cells into the tumour milieu, as well as a lack of specificity and persistence of their action hinders the potential of adoptive T cell therapy (ACT). To overcome these issues, we propose to arm T cells with synthetic agonistic receptors (SARs) that are conditionally activated only in the presence of a target tumour associated antigen, and a cross-linking bispecific antibody (BiAb) specific for both T cell and tumour cell.
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