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Impact of natural substances on the efficacy of immunotherapy

      Background: Natural substances are well known to influence efficacy of a number of chemotherapeutic drugs. Both, supporting and inhibiting impact is reported. In contrast, information on the interaction of natural substances and immunotherapy is very preliminary. The present study aims to identify a) the therapeutic impact of Vitamin C, Curcumin, Artesunat on the PD-1/PDL-1 inhibitor Pembrolizumab and b) chances induced in the immunophenotype in colorectal cancer (CRC) patients.
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