Background: Three kits of immune-modulatory compounds, (GM-CSF, combined either with Picibanil
(Kit “I”), Prostaglandine (PG) E2 (Kit “K”) or PGE1 (Kit “M”)) were identified to
effectively convert myeloid blasts into dendritic cells of leukemic origin (DCleu). After stimulation with DCleu, antileukemic T-cells can be generated ex vivo (patent 102014014993). The compounds are approved for clinical use and are therefore
attractive tools for immunotherapy in myeloid leukemia. For in vivo testing, a rodent
model with AML-diseased rats was used: Three rats each were treated with “I”, “K”
or “M”. Untreated animals with AML and healthy rats served as controls. A significant
reduction of blasts was seen with “M” (p=0.03/0.0001 in spleen/PB) and “I”, but not
“K”. Successful treatment correlated with an increase of CD62L+ cells, most likely
representing Tmem-cells, (p=0.07) and a reduction of CD4+Treg (p=0.037). Based on these data, an individual salvage treatment was performed in
a patient with refractory AML.
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© 2018 Published by Elsevier Inc.
