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MiRNA set dysregulation in breast cancer cells can contribute to both primary and acquired resistance to immune checkpoint blockade

      Background: One of the main immune escape mechanisms used by tumors is the exploitation of immune checkpoints – receptors on surface of immune cells, which, after binding their ligands, can suppress immune response. Consequently, immune checkpoint blockade is considered as promising approach for cancer treatment. However, currently available anti-CTLA-4 and anti-PD-1/anti-PD-L1 drugs have shown limited efficiency against many common cancer types (e.g. breast cancer). This research aims to identify in what way the shifts in miRNA expression pattern can contribute to the resistance of breast cancer cells to the immune checkpoint inhibitors and to the weakening of their efficiency during treatment.
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