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The influence of stromal cells on CD3+ CD8+ tumor infiltrating lymphocyte subpopulations in cancer microtissues

  • S. Koeck
    Correspondence
    Corresponding author. Medical University of Innsbruck, Department of Internal Medicine V, Innsbruck, Austria.
    Affiliations
    Medical University of Innsbruck, Department of Internal Medicine V, Innsbruck, Austria

    Tyrolean Cancer Research Institute, Innsbruck, Austria
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  • M. Zwierzina
    Affiliations
    Medical University of Innsbruck, Department of Plastic, Reconstructive and Aesthetic Surgery, Innsbruck, Austria
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  • G. Gamerith
    Affiliations
    Medical University of Innsbruck, Department of Internal Medicine V, Innsbruck, Austria

    Tyrolean Cancer Research Institute, Innsbruck, Austria
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  • E. Lorenz
    Affiliations
    Medical University of Innsbruck, Department of Internal Medicine V, Innsbruck, Austria

    Tyrolean Cancer Research Institute, Innsbruck, Austria
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  • H. Zwierzina
    Affiliations
    Medical University of Innsbruck, Department of Internal Medicine V, Innsbruck, Austria

    Tyrolean Cancer Research Institute, Innsbruck, Austria
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  • J. Kern
    Affiliations
    Medical University of Innsbruck, Department of Internal Medicine V, Innsbruck, Austria

    Tyrolean Cancer Research Institute, Innsbruck, Austria
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  • A. Amann
    Affiliations
    Medical University of Innsbruck, Department of Internal Medicine V, Innsbruck, Austria

    Tyrolean Cancer Research Institute, Innsbruck, Austria
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      Background: The tumor stroma is known to be significantly involved in the interaction between cancer tissues and the immune system. In this work, we investigate the influence of cancer associated fibroblasts on the secretion of cytotoxic T lymphocyte specific chemokines within cancer tissues and immune cell infiltration using a multicellular 3D co-culture system.
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