Background: A cornerstone of the biological process which mediates response to immunotherapy
in cancer patients is the expression of neoantigens resulting from somatic mutations
in cancer cells. Little attention has been paid so far to the neoantigen’s immune
cell counterpart, the T-cell receptor (TCR). In this study, we aimed at characterizing
the tumor infiltrating T-cell repertoire in colorectal cancer (CRC), and to evaluate
evidence for neoantigen driven T-cell expansion within the tumor microenvironment.
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© 2018 Published by Elsevier Inc.
