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The role of myeloid-derived suppressor cells in autologous hematopoietic stem cell transplantation

      Background: Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of immature, immunosuppressive cells that play a role in cancer induction, progression and immune evasion. Two major MDSC subsets exist: polymorphonuclear (PMN-MDSC) and monocytic MDSC (M-MDSC). Recent studies indicated that the immune reconstitution after autologous hematopoietic stem cell transplantation (ASCT) is associated with outcome. Since MDSC are immunosuppressive cells, we hypothesize that they play a role in the immune reconstitution after ASCT.
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