Background: Despite intensified research over the past years on the impact of the immune response
in human cancer tissues, most novel insights remain restricted to the interplay between
tumour cells, lymphocytes and macrophages, the main drivers in the cancer immunity
cycle, whereas much of our current knowledge on mast cells is transferred from their
long known involvement in allergic reactions. In a multitude of studies, the impact
of mast cell numbers and localization within the tumour microenvironment on patient
outcome has been analysed - however present knowledge did not yield an unambiguous
consensus with clinical data yet, mainly emphasizing that the presence of mast cells
contributes to a complex functional network between immune and cancer cells and that
their effects are not only depending on clinical aspects like tumour entity, TNM and
grading, but also on their spatial distribution and activation status. Preliminary
results, indicating an accumulation of tryptase+ cells around adipocyte rich areas led to a further examination of their localization
and effector status in comparison between fat cell rich and non fat cell containing
tumour tissues.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to European Journal of CancerAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
Article info
Publication history
P02.05
Identification
Copyright
© 2018 Published by Elsevier Inc.
