Omental fat in ovarian cancer induces lymphangiogenesis

      Background: Ovarian cancer metastasis occurs by direct multifocal seeding in the peritoneum as well as by migration through the lymphatic system. High grade ovarian carcinoma patients present distant metastases. Significant risk factors for the development of those are stage, grade, and lymph node involvement. An increase of the number of lymphatic vessels is shown in ovarian tumor and these vessels seem implicated in tumor progression. While the tropism of ovarian cancer cells for fat is well described, the potential impact of a fatty microenvironment on the dissemination of metastasis via lymphatic vessels has never been investigated. In this study, we examined the effect of omental fat on lymphangiogenesis in ovarian carcinoma
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