Background: Platelet-induced cancer progression is a well-known process driven by mitogenic factors
released by activated platelets, among them the most pro-oncogenic is Latent Transforming
Growth Factor Beta (LTGFβ). Glycoprotein-A Repetitions Predominant Protein (GARP),
a receptor for LTGFβ that enhances its bio-activation, is expressed by regulatory
T cells, platelets, and several human cancers. Upon activation platelets dramatically
upregulate GARP. This suggests that GARP might play a role in activating LTGFβ released
upon platelet degranulation and thus in platelet-induced cancer progression.
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© 2018 Published by Elsevier Inc.
