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GARP-TGFβ axis on activated platelets supports tumor progression

      Background: Platelet-induced cancer progression is a well-known process driven by mitogenic factors released by activated platelets, among them the most pro-oncogenic is Latent Transforming Growth Factor Beta (LTGFβ). Glycoprotein-A Repetitions Predominant Protein (GARP), a receptor for LTGFβ that enhances its bio-activation, is expressed by regulatory T cells, platelets, and several human cancers. Upon activation platelets dramatically upregulate GARP. This suggests that GARP might play a role in activating LTGFβ released upon platelet degranulation and thus in platelet-induced cancer progression.
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