Omental fat in ovarian cancer induces metabolic and immune alterations

      Background: Ovarian cancer frequently presents itself with established metastasis-like disseminated tumor islets along the fatty omentum. While the tropism of ovarian cancer cells for fat is well described, the potential impact of a fatty microenvironment on the anti-tumor immune response is unclear. In this study, we investigated the effect of fat on immune cell infiltration, distribution across tissue, and activation status.
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