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The use of EGFR-CD3 bispecific antibody and antigen-specific high avidity T cells to target cancer associated fibroblasts and cancer cells within a melanoma organoid system

      Background: The interactions between cancer cells and cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME) are important for local tumor progression and metastasis. CAFs make up the majority of the cell population in the TME and can effectively inhibit an immune response by acting as both a physical barrier and immunosuppressive agent. In this report, we developed a novel immune-based approach to treat a solid tumor through the use of melanoma-specific high-avidity cytotoxic T lymphocytes (HACTL) and bispecific antibodies (BsAbs) to target melanoma cells and CAFs.
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