Background: Tumor-infiltrating lymphocytes (TILs) are restrained by the tumor environment thereby
precluding tumor rejection. If similar deviations in the rejection capacity of TILs
can be identified across different tumor entities, this would open the way for anti-tumor
immunotherapy. Functional non-responsiveness can be mediated through multiple non-exclusive
mechanisms including exhaustion, tolerance, anergy or cellular inhibition. We have
previously described that CD8+ TILs of clear cell renal cell carcinoma (ccRCC) show
an anergic phenotype with high levels of diacylglycerol kinase-α (DGK-α) and low levels
of extracellular-signal regulated kinase (ERK) phosphorylation associated with lack
of cytotoxic function and inability to respond to CD3 stimulation [1].The goal of
this project is to analyze the immune infiltrate in ccRCC and non-virus associated
hepatocellular carcinoma (nv-HCC) patients.
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Publication history
Plenary Symposium 2: Emerging concepts / novel agents A1
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© 2018 Published by Elsevier Inc.
