Highlights
- •The limitations of randomised clinical trials to evidence-based medicine are reviewed.
- •Complementary strategies based on exploiting population-based registries and electronic health records are discussed.
- •A novel approach combining population-based registry and electronic health record features is proposed.
Abstract
Randomised clinical trials (RCTs) are considered the basis of evidence-based medicine.
It is recognised more and more that application of RCT results in daily practice of
clinical decision-making is limited because the RCT world does not correspond with
the clinical real world. Recent strategies aiming at substitution of RCT databases
by improved population-based registries (PBRs) or by improved electronic health record
(EHR) systems to provide significant data for clinical science are discussed. A novel
approach exemplified by the HemoBase haemato-oncology project is presented. In this
approach, a PBR is combined with an advanced EHR, providing high-quality data for observational studies and support of best practice
development. This PBR + EHR approach opens a perspective on randomised registry trials.
Keywords
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Article info
Publication history
Published online: October 06, 2017
Accepted:
September 4,
2017
Received in revised form:
September 1,
2017
Received:
July 31,
2017
Identification
Copyright
© 2017 Elsevier Ltd. All rights reserved.
