Highlights
- •SOX9 has a dose-dependent effect in intestine epithelial cells.
- •High dose of SOX9 is found in quiescent reserve intestinal stem cells.
- •Low dose of SOX9 is found in actively proliferating intestinal stem cells.
- •High level of SOX9 predicts a low risk of relapse in stage II CRC.
- •10% of colorectal cancers exhibit heterozygous inactivating mutations of SOX9.
Abstract
A member of the Sry-related HMG-box family of transcription factors (SOX9) is a transcription factor
that belongs to the superfamily of High Mobility Group (HMG) domain transcription
factors. SOX9 is expressed in a variety of tissues, including as the intestinal epithelium,
where it is now recognised as an important actor for homeostasis. Beside, a high level
of SOX9 has recently been correlated with a good prognosis for stage II colorectal
cancers. However, growing evidence indicates that deciphering the function of SOX9
in the intestine has to take into account a dose-dependent effect of SOX9. Given the
recurrent controversies and the lack of a state of the art as to whether SOX9 behaves
like a tumour suppressor or an oncogen in the intestine epithelium, it is time to
provide an update of the accumulated knowledge about the biological function of SOX9
in the intestine and about the role of SOX9 in colorectal cancers.
Keywords
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Article info
Publication history
Published online: October 06, 2017
Accepted:
August 30,
2017
Received in revised form:
August 24,
2017
Received:
May 18,
2017
Identification
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