Highlights
- •Only 32 economic evaluations (EEs) have been published over the past 15-years.
- •A wide variety of methodological approaches were shown.
- •Nearly two-thirds of EEs are full and 40% are cost-utility analyses.
- •Only nearly one-third of EEs are of high quality.
- •Need to apply European and international recommendations to ensure quality of EEs.
Abstract
Objectives
The economic evaluation (EE) of healthcare interventions has become a necessity. However,
high quality needs to be ensured in order to achieve validated results and help making
informed decisions. Thus, the objective of the present study was to systematically
identify and review published pancreatic ductal adenocarcinoma-related EEs and to
assess their quality.
Methods
Systematic literature research was conducted in PubMed and Cochrane to identify published
EEs between 2000 and 2015. The quality of each selected EE was assessed by two independent
reviewers, using the Drummond's checklist.
Results
Our systematic review was based on 32 EEs and showed a wide variety of methodological
approaches, including different perspectives, time horizon, and cost effectiveness
analyses. Nearly two-thirds of EEs are full EEs (n = 21), and about one-third of EEs
had a Drummond score ≥7, synonymous with ‘high quality’. Close to 50% of full EEs
had a Drummond score ≥7, whereas all of partial EEs had a Drummond score <7 (n = 11).
Conclusions
Over the past 15 years, a lot of interest has been evinced over the EE of pancreatic
ductal adenocarcinoma (PDAC) and its direct impact on therapeutic advances in PDAC.
To provide a framework for health care decision-making, to facilitate transferability
and to lend credibility to health EEs, their quality must be improved. For the last
4 years, a tendency towards a quality improvement of these studies has been observed,
probably coupled with a context of rational decision-making in health care, a better
and wider spread of recommendations and thus, medical practitioners' full endorsement.
Keywords
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Article info
Publication history
Published online: October 09, 2017
Accepted:
August 30,
2017
Received in revised form:
August 8,
2017
Received:
May 4,
2017
Identification
Copyright
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