Highlights
- •The limits and the consequences of the current development of anticancer therapeutic innovations in Europe.
- •The EORTC advocates for a paradigm shift from an ‘innovation-centred’ to a truly ‘patient-centred’ approach.
- •The new paradigm features interconnected partnership among stakeholders and independent research infrastructure coordination.
Abstract
In Europe, most of the cancer clinical research dedicated to therapeutic innovations
aims primarily at regulatory approval. Once an anticancer drug enters the common market,
each member state determines its real-world use based on its own criteria: pricing,
reimbursement and clinical indications. Such an innovation-centred clinical research
landscape might neglect patient-relevant issues in real-world setting, such as comparative
effectiveness of distinct treatment options or long-term safety monitoring.
The European Organisation for Research and Treatment of Cancer (EORTC) advocates reforming
the current ‘innovation-centred’ system to a truly ‘patient-centred’ paradigm with
systematically coordinated applied clinical research in conjunction with drug development,
featuring the following strategy:
- (1)An interconnected partnership among key-stakeholders involved in the care delivery system, namely patients, health professionals, academia, pharmaceutical industry, regulators, payers and policy-makers, to optimise the transition from research to clinical practice and vice versa;
- (2)An independent research infrastructure host and coordination ensuring independent, high quality and sustainable research.
Keywords
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Article info
Publication history
Published online: October 04, 2017
Accepted:
August 23,
2017
Received:
August 21,
2017
Identification
Copyright
© 2017 Elsevier Ltd. All rights reserved.
