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☆This publication arises from the project ExPO-r-Net which has received funding from the European Union in the framework of the Health Programme (2008–2013), grant agreement nr. 2013 12 07.
☆☆Kathy Pritchard-Jones is in part supported by the National Institute for Health Research, Great Ormond Street Hospital, UCL Biomedical Research Centre, Cancer Research UK (C1188/A4614), Great Ormond Street Hospital Children's Charity, and the European Commission FP7 project reference 261474: European Network for Cancer Research in Children and Adolescents.