Original Research| Volume 55, P38-46, March 2016

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Bilateral salpingectomy can reduce the risk of ovarian cancer in the general population: A meta-analysis

  • Sang-Hee Yoon
    Department of Obstetrics and Gynecology, Sanggye Paik Hospital, Inje University School of Medicine, Seoul, South Korea
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  • Soo-Nyung Kim
    Department of Obstetrics and Gynecology, Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, South Korea
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  • Seung-Hyuk Shim
    Department of Obstetrics and Gynecology, Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, South Korea
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  • Soon-Beum Kang
    Department of Obstetrics and Gynecology, Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, South Korea
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  • Sun-Joo Lee
    Corresponding author: Department of Obstetrics and Gynecology, Konkuk University School of Medicine, 1 Hwayang-dong, Gwangjin-gu, Seoul 143-701, South Korea. Tel.: +82 2 2030 7644; fax: +82 2 2030 7748.
    Department of Obstetrics and Gynecology, Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, South Korea
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Published:January 08, 2016DOI:


      • The bilateral salpingectomy (BS) reduces the risk of ovarian cancer (OC) by 49%.
      • The BS is an effective measure to reduce OC risk in the general population.
      • The BS could avoid the development of a consecutive tubal pathology.
      • The BS did not have any short-term deleterious effects on ovarian reserve.
      • The BS should be considered for women requiring hysterectomy with benign indications.



      The results of recent studies have suggested that high-grade serous ovarian cancer predominantly arises within the fallopian tubes. The reduction of ovarian cancer (OC) risk in women with a history of bilateral salpingectomy (BS) has been reported. We performed a meta-analysis to determine the impact of BS in preventing OC in the general population.


      We searched the PubMed, MEDLINE, and EMBASE databases and CENTRAL in the Cochrane Library for all English-language articles published up to January 2015, using the key words ‘ovarian cancer’ and ‘bilateral salpingectomy.’ Odds ratios (ORs) and their 95% confidence intervals (95% CIs) were calculated by standard meta-analysis techniques.


      Of the 77 studies retrieved, three were included in this meta-analysis, including one cohort study and two population-based case-control studies with 3509 patients who underwent BS and 5,655,702 controls who did not undergo salpingectomy. Over the combined study period, 29 of the 3509 BS patients developed OC compared with 44,006 of the 5,655,702 without salpingectomy. The meta-analysis results based on the fixed effects model revealed a significant decrease in the risk of OC occurrence in the patients who underwent BS relative to the controls (OR=0.51, 95% CI 0.35–0.75, I2=0%). This pattern was also observed in subgroup analysis for the study type.


      Our results suggest that removal of the fallopian tubes is an effective measure to reduce OC risk in the general population. Therefore, prophylactic bilateral salpingectomy should be considered for women who require hysterectomy with benign indications or sterilisation procedures.


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