Highlights
- •HNSCC tumor sequencing has identified new pathogenic pathways and therapeutic targets.
- •Multidisciplinary ‘personalised medicine’ tumour boards may radically alter HNSCC intervention.
- •The integration of genetics data with clinical decision making requires collaboration.
- •CCND1 and CDKN2A genomic alterations correlate with poor overall survival in HNSCC.
Abstract
Personalised medicine tumour boards, which leverage genomic data to improve clinical
management, are becoming standard for the treatment of many cancers. This paper is
designed as a primer to assist clinicians treating head and neck squamous cell carcinoma
(HNSCC) patients with an understanding of the discovery and functional impact of recurrent
genetic lesions that are likely to influence the management of this disease in the
near future. This manuscript integrates genetic data from publicly available array
comparative genome hybridization (aCGH) and next-generation sequencing genetics databases
to identify the most common molecular alterations in HNSCC. The importance of these
genetic discoveries is reviewed and how they may be incorporated into clinical care
decisions is discussed. Considerations for the role of genetic stratification in the
clinical management of head and neck cancer are maturing rapidly and can be improved
by integrating data sets. This article is meant to summarise the discoveries made
using multiple genomic platforms so that the head and neck cancer care provider can
apply these discoveries to improve clinical care.
Keywords
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Article info
Publication history
Published online: February 03, 2016
Accepted:
October 28,
2015
Received:
October 19,
2015
Footnotes
☆“This article was written by members and invitees of the International Head and Neck Scientific Group (www.IHNSG.com)”.
Identification
Copyright
© 2015 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
