Abstract| Volume 51, SUPPLEMENT 1, S7, March 2015

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ITOC2 – 018. Hyperthermia induced immunogenic cell-death

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      Some hyperthermia studies in oncology deals with connected immune-effects. Modulated electro-hyperthermia (oncothermia, Szasz et al. (2010) [
      • Szasz A.
      • et al.
      Oncothermia. Principles and Practices.
      ]) is an emerging curative treatment method. It is selectively focused in the malignant cells without harming the non-malignant surrounding tissues Andocs et al. (2009) [
      • Andocs G.
      • et al.


      Our objective is studying the cell-death process caused by the treatment.


      HT29 human colorectal xenograft and C26 mouse colorectal allograft models were studied in vivo, on in time-course investigations. We apply 13.56 MHz radiofrequency (RF) signal modulated by 1/f noise pattern. In silico models were performed visualising the selection process. Samples were analysed by various histomorphological and immunhistochemical analyses.


      A massive TUNEL positivity was produced. Up regulation of TRAILR2 (DR5), FAS and FADD was observed. AIF nuclear translocalisation together with mitochondrial pore formation and cytochrome-C release, as well as DNA fragmentation was measured. A damage associated molecular pattern (DAMP) was formed, which are probably parts of the immunogenic cell-death (ICD) of the selected malignant cells.


      The DAMP associated, induced ICD can be a good basis for hyperthermia and immunotherapy combination.
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        • Szasz A.
        • et al.
        Oncothermia. Principles and Practices.
        Springer, 2010
        • Andocs G.
        • et al.
        Electrom Biol Med. 2009; 28: 148-165