This paper is only available as a PDF. To read, Please Download here.
Some hyperthermia studies in oncology deals with connected immune-effects. Modulated electro-hyperthermia (oncothermia, Szasz et al. (2010) [
1]) is an emerging curative treatment method. It is selectively focused in the malignant cells without harming the non-malignant surrounding tissues Andocs et al. (2009) [
- Szasz A.
- et al.
Oncothermia. Principles and Practices.
- Andocs G.
- et al.
Electrom Biol Med. 2009; 28: 148-165
Our objective is studying the cell-death process caused by the treatment.
HT29 human colorectal xenograft and C26 mouse colorectal allograft models were studied in vivo, on in time-course investigations. We apply 13.56 MHz radiofrequency (RF) signal modulated by 1/f noise pattern. In silico models were performed visualising the selection process. Samples were analysed by various histomorphological and immunhistochemical analyses.
A massive TUNEL positivity was produced. Up regulation of TRAILR2 (DR5), FAS and FADD was observed. AIF nuclear translocalisation together with mitochondrial pore formation and cytochrome-C release, as well as DNA fragmentation was measured. A damage associated molecular pattern (DAMP) was formed, which are probably parts of the immunogenic cell-death (ICD) of the selected malignant cells.
The DAMP associated, induced ICD can be a good basis for hyperthermia and immunotherapy combination.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to European Journal of Cancer
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Oncothermia. Principles and Practices.Springer, 2010
- Electrom Biol Med. 2009; 28: 148-165