Abstract
Aim
The aim of this retrospective, registry-based study was to analyse treatment outcomes
in patients with metastatic renal cell carcinoma (mRCC) treated with sunitinib and
renal insufficiency (RI).
Methods
The cohort included 790 patients treated with sunitinib between 2006 and 2013. At
the start of sunitinib therapy 22, 234, and 534 patients had severe (glomerular filtration
rate [GFR] <30 ml/min/1.73 m2), moderate (GFR 30–60 ml/min/1.73 m2) or mild RI/normal renal function (GFR >60 ml/min/1.73 m2), respectively.
Results
For the three groups defined above, median progression-free survival (PFS) (95% confidence
interval [CI]) was 5.3 months (0.1–18.5), 8.1 months (6.2–9.9) and 11.3 months (9.4–13.2) (p = 0.244), and median overall survival (OS) was 26.3 months (1.2–51.4), 21.2 months (13.2–29.1) and 26.3 months (22.6–29.9) (p = 0.443), respectively. The disease control rates were 45.5%, 56.4% and 59.2%, respectively
(p = 0.374). No unexpected toxicity was reported in the patients with RI, but the treatment
was more frequently discontinued because of adverse events and the duration of therapy
was significantly shorter in these patients (p = 0.007).
Conclusions
Duration of first-line targeted treatment for mRCC was significantly shorter for patients
with RI, and may have translated into a trend to shorter PFS. These results highlight
the need for optimal management of side-effects in patients with mRCC and RI.
Keywords
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Article info
Publication history
Published online: January 07, 2015
Accepted:
December 14,
2014
Received in revised form:
November 29,
2014
Received:
September 14,
2014
Identification
Copyright
© 2015 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
