Abstract
Chlamydia pneumoniae (C. pneumoniae) is a common cause of acute respiratory infection and has been hypothesised to cause
several chronic diseases, including lung cancer. Numbers studies were conducted to
analyse the association between C. pneumoniae infection and risk of lung cancer, but no clear consensus had been found. To assess
this relationship more precisely, a meta-analysis was performed. The electronic databases
PubMed, Embase, Web of Science and CNKI were searched; Data were extracted and analysed
independently by two investigators. Ultimately, 12 studies, involving 2595 lung cancer
cases and 2585 controls from four prospective studies and eight retrospective studies
were included. Overall, people exposed to C. pneumoniae infection had an odds ratio (OR) of 1.48 (95% confidence interval (CI), 1.32–1.67)
for lung cancer risk, relative to those not exposed. C. pneumoniae infection was clearly identified as a risk factor for lung cancer in both prospective
studies (OR, 1.16; 95% CI, 1.00–1.36) and retrospective studies (OR, 2.17; 95% CI,
1.79–2.63) and in both IgA ⩾ 16 cutoff group (OR, 1.22; 95% CI, 1.06–1.41) and the IgA ⩾ 64 cutoff group (OR, 2.35; 95% CI, 1.88–2.93). In conclusion, C. pneumoniae infection is associated with an increased risk for lung cancer, higher titre may
be a better predictor of lung cancer risk.
Keywords
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Article info
Publication history
Published online: January 03, 2011
Accepted:
November 3,
2010
Received in revised form:
October 29,
2010
Received:
August 30,
2010
Identification
Copyright
© 2010 Published by Elsevier Inc.
