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Chlamydia pneumoniae infection and lung cancer risk: A meta-analysis

  • Ping Zhan
    Affiliations
    First Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, China
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  • Li-jun Suo
    Affiliations
    Department of Respiratory Medicine, The Affiliated Linzi District People ‘s Hospital of Binzhou Medical University, Zibo, China
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  • Qian Qian
    Affiliations
    First Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, China
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  • Xiao-kun Shen
    Affiliations
    Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China
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  • Li-Xin Qiu
    Affiliations
    Department of Medical Oncology, Cancer Hospital, Shanghai Medical College, Fudan University, Shanghai, China
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  • Li-ke Yu
    Correspondence
    Corresponding authors: Address: First Department of Respiratory Medicine, Nanjing Chest Hospital, 215 Guangzhou Road, Nanjing 210029, China. Tel./fax: +86 25 8372 8558 (L.-k. Ye). Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, 305 East Zhongshan Road, Nanjing 210002, China. Tel./fax: +86 25 8086 3591 (Y. Song).
    Affiliations
    First Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, China
    Search for articles by this author
  • Yong Song
    Correspondence
    Corresponding authors: Address: First Department of Respiratory Medicine, Nanjing Chest Hospital, 215 Guangzhou Road, Nanjing 210029, China. Tel./fax: +86 25 8372 8558 (L.-k. Ye). Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, 305 East Zhongshan Road, Nanjing 210002, China. Tel./fax: +86 25 8086 3591 (Y. Song).
    Affiliations
    Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China
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Published:January 03, 2011DOI:https://doi.org/10.1016/j.ejca.2010.11.003

      Abstract

      Chlamydia pneumoniae (C. pneumoniae) is a common cause of acute respiratory infection and has been hypothesised to cause several chronic diseases, including lung cancer. Numbers studies were conducted to analyse the association between C. pneumoniae infection and risk of lung cancer, but no clear consensus had been found. To assess this relationship more precisely, a meta-analysis was performed. The electronic databases PubMed, Embase, Web of Science and CNKI were searched; Data were extracted and analysed independently by two investigators. Ultimately, 12 studies, involving 2595 lung cancer cases and 2585 controls from four prospective studies and eight retrospective studies were included. Overall, people exposed to C. pneumoniae infection had an odds ratio (OR) of 1.48 (95% confidence interval (CI), 1.32–1.67) for lung cancer risk, relative to those not exposed. C. pneumoniae infection was clearly identified as a risk factor for lung cancer in both prospective studies (OR, 1.16; 95% CI, 1.00–1.36) and retrospective studies (OR, 2.17; 95% CI, 1.79–2.63) and in both IgA ⩾ 16 cutoff group (OR, 1.22; 95% CI, 1.06–1.41) and the IgA ⩾ 64 cutoff group (OR, 2.35; 95% CI, 1.88–2.93). In conclusion, C. pneumoniae infection is associated with an increased risk for lung cancer, higher titre may be a better predictor of lung cancer risk.

      Keywords

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