Abstract
Aim of the study
To examine risk factors for developing hypertension in childhood cancer survivors
(CCS).
Methods
We conducted a nested case-control study of risk for hypertension within a cohort
of 1362 childhood cancer survivors treated between 1966 and 1996 in the Emma’s Children’s
Hospital/Academic Medical Center in the Netherlands. Detailed information on treatment
and several lifestyle factors was collected for 44 cases with hypertension and 123
matched controls. Odds ratios (ORs) for hypertension were calculated by conditional
logistic regression analysis.
Results
Body Mass Index (BMI) was the only significant risk factor associated with the occurrence
of hypertension (OR 3.95; 95% confidence interval (CI) 1.7–9.1 for BMI ⩾ 25 kg/m2 compared to BMI < 25 kg/m2). However, cisplatin, cyclophosphamide and radiotherapy (RT) to the abdominal region
were all associated with non-significant risk increases (ORs of 4.3, 2.1, and 1.8,
respectively).
Conclusion
Our results show that BMI is the most important risk factor for hypertension following
treatment of childhood cancer, emphasising the need for CCS to maintain a normal weight.
Keywords
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Article info
Publication history
Published online: February 01, 2010
Accepted:
January 6,
2010
Received in revised form:
December 28,
2009
Received:
April 11,
2009
Identification
Copyright
© 2010 Published by Elsevier Inc.
