Abstract
The result of reirradiation in recurrent T1 (rT1) nasopharyngeal carcinoma (NPC) is
unsatisfactory. We sought to study the efficacy and complications of endoscopic microwave
coagulation therapy (MCT) in salvaging rT1 NPC after primary radiotherapy. Between
August 1994 and April 2005, 55 patients with rT1 NPC were treated with endoscopic
MCT. With a median follow-up of 102.1 months, 52 of 55 patients are still alive. Five patients had local failure after retreatment.
The overall survival and local progression-free survival were 100% (95% CI, 99.4%
to 100%) and 94.5% (95% CI, 94.1% to 94.9%) at 2 years, respectively, and 93.6% (95% CI, 93.5% to 94.4%) and 90.7% (95% CI, 90.2% to
91.2%) at 5 years. The common complications of endoscopic MCT were mild postoperative pain and
headache. Nasopharyngeal necrosis was transient in one patient and subsided in 1 month. Endoscopic MCT achieved significant survival and tumour control without severe
complications in selective rT1 NPC.
Keywords
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Article info
Publication history
Published online: March 27, 2009
Accepted:
February 27,
2009
Received in revised form:
February 18,
2009
Received:
December 18,
2008
Identification
Copyright
© 2009 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
