Abstract
Neoadjuvant chemotherapy is used in women who have large or locally advanced breast
cancers. However, up to 70% of women who receive neoadjuvant chemotherapy fail to
achieve a complete pathological response in their primary tumour (a surrogate marker
of long-term survival). Five proteins, previously identified to be linked with chemoresistance
in our in vitro experiments, were identified histochemically in pre-treatment core needle biopsies
from 40 women with large or locally advanced breast cancers. Immunohistochemical staining
with the five proteins showed no single protein to be a predictor of response to chemotherapy.
However, pre-treatment breast cancer specimens that were annexin-A2 positive but annexin-A1
negative correlated with a poor pathological response (p = 0.04, Fisher’s exact test). The mechanisms by which annexins confer chemoresistance
have not been identified, but may be due to inhibition of apoptosis. Annexin-A1 has
been shown to enhance apoptosis, whilst annexin-A2, by contrast, inhibits apoptosis.
Keywords
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Article info
Publication history
Published online: January 27, 2009
Accepted:
December 19,
2008
Received in revised form:
December 17,
2008
Received:
June 10,
2008
Identification
Copyright
© 2008 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
