Advertisement
Research Article| Volume 45, ISSUE 7, P1248-1256, May 2009

Download started.

Ok

The impact of socioeconomic factors on 30-day mortality following elective colorectal cancer surgery: A nationwide study

  • B.L. Frederiksen
    Correspondence
    Corresponding author: Tel.: +45 43 23 32 83; fax: +45 43 23 39 77.
    Affiliations
    Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup University Hospital, Building 84/85, DK-2600 Glostrup, Denmark
    Search for articles by this author
  • M. Osler
    Affiliations
    Institute of Public Health, Department of Social Medicine, University of Copenhagen, 1014 Copenhagen K, Denmark
    Search for articles by this author
  • H. Harling
    Affiliations
    Department of Surgery K, Bispebjerg University Hospital, 2400 Copenhagen NV, Denmark
    Search for articles by this author
  • on behalf of Danish Colorectal Cancer Group
  • Steen Ladelund
    Affiliations
    Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup University Hospital, Building 84/85, DK-2600 Glostrup, Denmark
    Search for articles by this author
  • T. Jørgensen
    Affiliations
    Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup University Hospital, Building 84/85, DK-2600 Glostrup, Denmark

    Institute of Public Health, Department of Social Medicine, University of Copenhagen, 1014 Copenhagen K, Denmark
    Search for articles by this author
Published:January 12, 2009DOI:https://doi.org/10.1016/j.ejca.2008.11.035

      Abstract

      We investigated postoperative mortality in relation to socioeconomic status (SES) in electively operated colorectal cancer patients, and evaluated whether social inequalities were explained by factors related to patient, disease or treatment. Data from the nationwide database of Danish Colorectal Cancer Group were linked to individual socioeconomic information in Statistics Denmark. Patients born before 1921 and those having local surgical or palliative procedures were excluded. A total of 7160 patients, operated on in the period 2001–2004, were included, of whom 342 (4.8%) died within 30 days of surgery. Postoperative mortality was significantly lower in patients with high income (odds ratio (OR) = 0.82 (0.70–0.95) for each increase in annual income of EUR 13,500), higher education versus short education (OR) = 0.60 (0.41–0.87), and owner-occupied versus rental housing (OR) = 0.73 (0.58–0.93). Differences in comorbidity and to a lesser extent lifestyle characteristics accounted for the excess risk of postoperative death among low-SES patients.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to European Journal of Cancer
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • McCaffery K.
        • Wardle J.
        • Nadel M.
        • Atkin W.
        Socioeconomic variation in participation in colorectal cancer screening.
        J Med Screen. 2002; 9: 104-108
        • Whynes D.K.
        • Frew E.J.
        • Manghan C.M.
        • Scholefield J.H.
        • Hardcastle J.D.
        Colorectal cancer, screening and survival: the influence of socio-economic deprivation.
        Public Health. 2003; 117 (Nov): 389-395
        • Singh S.M.
        • Paszat L.F.
        • Li C.
        • He J.
        • Vinden C.
        • Rabeneck L.
        Association of socioeconomic status and receipt of colorectal cancer investigations: a population-based retrospective cohort study.
        CMAJ. 2004; 171 (Aug 31): 461-465
        • Frederiksen B.L.
        • Osler M.
        • Harling H.
        • Jorgensen T.
        Social inequalities in stage at diagnosis of rectal but not in colonic cancer: a nationwide study.
        Brit J Cancer. 2008; 98 (Feb 12): 668-673
        • Mandelblatt J.
        • Andrews H.
        • Kao R.
        • Wallace R.
        • Kerner J.
        The late-stage diagnosis of colorectal cancer: demographic and socioeconomic factors.
        Am J Public Health. 1996; 86 (Dec): 1794-1797
        • Parikh-Patel A.
        • Bates J.H.
        • Campleman S.
        Colorectal cancer stage at diagnosis by socioeconomic and urban/rural status in California, 1988–2000.
        Cancer. 2006; 107 (Sep 1): 1189-1195
        • Auvinen A.
        Social class and colon cancer survival in Finland.
        Cancer. 1992; 70 (Jul 15): 402-409
        • Wrigley H.
        • Roderick P.
        • George S.
        • Smith J.
        • Mullee M.
        • Goddard J.
        Inequalities in survival from colorectal cancer: a comparison of the impact of deprivation, treatment, and host factors on observed and cause specific survival.
        J Epidemiol Community Health. 2003; 57 (Apr): 301-309
        • Monnet E.
        • Boutron M.C.
        • Faivre J.
        • Milan C.
        Influence of socioeconomic status on prognosis of colorectal cancer. A population-based study in Cote D’Or, France.
        Cancer. 1993; 72 (Aug 15): 1165-1170
        • Schrijvers C.T.
        • Mackenbach J.P.
        • Lutz J.M.
        • Quinn M.J.
        • Coleman M.P.
        Deprivation, stage at diagnosis and cancer survival.
        Int J Cancer. 1995; 63 (Nov 3): 324-329
        • Du X.L.
        • Fang S.
        • Vernon S.W.
        • et al.
        Racial disparities and socioeconomic status in association with survival in a large population-based cohort of elderly patients with colon cancer.
        Cancer. 2007; 110 (Aug 1): 660-669
        • Smith J.J.
        • Tilney H.S.
        • Heriot A.G.
        • et al.
        Social deprivation and outcomes in colorectal cancer.
        Br J Surg. 2006; 93 (Sep): 1123-1131
      1. Danish Colorectal Cancer Group. Annual report 2004. Årsrapport 2004. Landsdækkende database for kræft i tyktarm og endetarm. Danish Colorectal Cancer Group; 2006.

      2. Statistics Denmark. IDA – an integrated database for labour market research. Main report; 1991.

        • Little R.J.A.
        • Rubin D.B.
        Statistical analysis with missing data.
        2nd ed. John Wiley & Sons, New Jersey2002
        • Nickelsen T.N.
        • Harling H.
        • Kronborg O.
        • Bulow S.
        • Jorgensen T.
        The completeness and quality of the Danish Colorectal Cancer clinical database on colorectal cancer.
        Ugeskr Laeger. 2004; 166 (Aug 30): 3092-3095
        • McLoone P.
        • Ellaway A.
        Postcodes don’t indicate individuals’ social class.
        BMJ. 1999; 319 (Oct 9): 1003-1004
        • Geyer S.
        • Hemstrom O.
        • Peter R.
        • Vagero D.
        Education, income, and occupational class cannot be used interchangeably in social epidemiology. Empirical evidence against a common practice.
        Journal of Epidemiology and Community Health. 2006; 60 (Sep 1): 804-810
        • Harrell Jr., F.
        Missing data. Regression modeling strategies: with applications to linear models, logistic regression, and survival analysis.
        1st ed. Springer-Verlag, New York2001 (p. 41–51)
        • Klebanoff M.A.
        • Cole S.R.
        Use of multiple imputation in the epidemiologic literature.
        Am J Epidemiol. 2008; 168 (Aug 15): 355-357
        • Sorensen L.T.
        • Jorgensen T.
        Short-term pre-operative smoking cessation intervention does not affect postoperative complications in colorectal surgery: a randomized clinical trial.
        Colorectal Dis. 2003; 5 (Jul): 347-352
        • From A.M.
        • Herlitz J.
        • Berndt A.K.
        • Karlsson T.
        • Hjalmarson A.
        Are patients truthful about their smoking habits? A validation of self-report about smoking cessation with biochemical markers of smoking activity amongst patients with ischaemic heart disease.
        J Int Med. 2001; 249 (Feb): 145-151
        • Hald J.
        • Overgaard J.
        • Grau C.
        Evaluation of objective measures of smoking status–a prospective clinical study in a group of head and neck cancer patients treated with radiotherapy.
        Acta Oncol. 2003; 42: 154-159
      3. Glümer C, Hilding-Nørkjær H, Nordahl-Jensen H, Jørgensen T, Andreasen AH, Ladelund S. Sundhedsprofil for Region og Kommuner i Region Hovedstaden 2008. 2008.

      4. National Institute of Public Health. Folkesundhedsrapporten, Danmark 2007. Copenhagen, National Institute of Public Health, University of Southern Denmark, 2007. Copenhagen; 2007.

        • Mackenbach J.P.
        • Kunst A.E.
        • Cavelaars A.E.
        • Groenhof F.
        • Geurts J.J.
        Socioeconomic inequalities in morbidity and mortality in Western Europe. The EU Working Group on Socioeconomic Inequalities in Health.
        Lancet. 1997; 349 (Jun 7): 1655-1659
        • De Marco M.F.
        • Janssen-Heijnen M.L.
        • van der Heijden L.H.
        • Coebergh J.W.
        Comorbidity and colorectal cancer according to subsite and stage: a population-based study.
        Eur J Cancer. 2000; 36 (Jan): 95-99
        • Janssen-Heijnen M.L.
        • Maas H.A.
        • Houterman S.
        • Lemmens V.E.
        • Rutten H.J.
        • Coebergh J.W.
        Comorbidity in older surgical cancer patients: influence on patient care and outcome.
        Eur J Cancer. 2007; 43 (Oct): 2179-2193
      5. Folkesundhedsrapporten, Denmark 2007. Copenhagen, National Institute of Public Health, University of Southern Denmark, 2007. Copenhagen; 2008.

        • Iversen L.H.
        • Bulow S.
        • Christensen I.J.
        • Laurberg S.
        • Harling H.
        Postoperative medical complications are the main cause of early death after emergency surgery for colonic cancer.
        Brit J Surg. 2008; 95 (Aug): 1012-1019
        • Kruschewski M.
        • Rieger H.
        • Pohlen U.
        • Hotz H.G.
        • Buhr H.J.
        Risk factors for clinical anastomotic leakage and postoperative mortality in elective surgery for rectal cancer.
        Int J Colorectal Dis. 2007; 22 (Aug): 919-927
        • Nickelsen T.N.
        • Jorgensen T.
        • Kronborg O.
        Lifestyle and 30-day complications to surgery for colorectal cancer.
        Acta Oncol. 2005; 44: 218-223
        • Tonnesen H.
        • Kehlet H.
        Preoperative alcoholism and postoperative morbidity.
        Br J Surg. 1999; 86 (Jul): 869-874
        • Sorensen L.T.
        • Jorgensen T.
        • Kirkeby L.T.
        • Skovdal J.
        • Vennits B.
        • Wille-Jorgensen P.
        Smoking and alcohol abuse are major risk factors for anastomotic leakage in colorectal surgery.
        Brit J Surg. 1999; 86 (Jul): 927-931
        • Dindo D.
        • Muller M.K.
        • Weber M.
        • Clavien P.A.
        Obesity in general elective surgery.
        Lancet. 2003; 361 (Jun 14): 2032-2035
        • Benoist S.
        • Panis Y.
        • Alves A.
        • Valleur P.
        Impact of obesity on surgical outcomes after colorectal resection.
        Am J Surg. 2000; 179 (Apr): 275-281
        • Calle E.E.
        • Rodriguez C.
        • Walker-Thurmond K.
        • Thun M.J.
        Overweight, obesity, and mortality from cancer in a prospectively studied cohort of US adults.
        N Engl J Med. 2003; 348 (Apr 24): 1625-1638
        • Harling H.
        • Bulow S.
        • Kronborg O.
        • Moller L.N.
        • Jorgensen T.
        Survival of rectal cancer patients in Denmark during 1994–99.
        Colorectal Dis. 2004; 6 (May): 153-157
        • Iversen L.H.
        • Harling H.
        • Laurberg S.
        • Wille-Jorgensen P.
        Influence of caseload and surgical speciality on outcome following surgery for colorectal cancer: a review of evidence Part 1: short-term outcome.
        Colorectal Dis. 2007; 9 (Jan): 28-37
        • Fazio V.W.
        • Tekkis P.P.
        • Remzi F.
        • Lavery I.C.
        Assessment of operative risk in colorectal cancer surgery: the Cleveland Clinic Foundation colorectal cancer model.
        Dis Colon Rectum. 2004; 47 (Dec): 2015-2024