Abstract
Aim
The aim of this study was to develop a bone metastases module to supplement the European
Organisation for Research and Treatment of Cancer Core Questionnaire (EORTC QLQ-C30)
or the EORTC QLQ-C15-PAL for patients with bone metastases.
Methods
Phases 1–2 of module development were conducted in Canada, Australia and Germany according
to EORTC QOL group guidelines. Phase 3 was conducted in nine countries in seven languages.
Results
Sixty-one health-related quality of life (HRQOL) issues were generated from health
care professionals (n = 152) and patients (n = 413). This resulted in a 22-item provisional module. Further testing in 170 patients
from nine countries resulted in the EORTC QLQ-BM22 module, containing 22 items, conceptualised
into both symptom scales, with five painful sites and three pain characteristics,
and also functional scales, with eight functional interference and six psychosocial
aspects.
Conclusion
This study provides a provisional comprehensive HRQOL measurement tool for future
trials, which will continue to undergo further validation.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to European Journal of CancerAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
Pain palliation of bone metastases – overview. InSightec.com. InSightec Image Guided Treatment Ltd. 1st April 2005 <http://www.insightec.com/135-en-r10/BoneMetastases.aspx>.
- Bone markers in multiple myeloma.Eur J Cancer. 2006; 42: 1544-1553
- Oral ibandronate improves bone pain and preserves quality of life in patients with skeletal metastases due to breast cancer.Pain. 2004; 111: 306-312
- Pain relief and quality-of-life assessment following intravenous and oral clodronate in hormone-escaped metastatic prostate cancer.Brit J Urol. 1995; 76: 360-365
- Improved quality of life after long-term treatment with the bisphosphonate ibandronate in patients with metastatic bone disease due to breast cancer.Eur J Cancer. 2004; 40: 1704-1712
- Randomized, double-blind, controlled trial of mitoxantrone/prednisone and clodronate versus mitoxantrone/prednisone and placebo in patients with hormone-refractory prostate cancer and pain.J Clin Oncol. 2003; 21: 3335-3342
- Skeletal response to clodronate in prostate cancer with bone metastases.Am J Clin Oncol. 1997; 20: 471-476
- Oral clodronate in breast cancer patients with bone metastases: a randomized study.J Intern Med. 1999; 246: 67-74
- Pamidronate prevents skeletal complications and is effective palliative treatment in women with breast carcinoma and osteolytic bone metastases.Cancer. 2000; 88: 1082-1090
- Efficacy and safety of ibandronate in the treatment of opioid-resistant bone pain associated with metastatic bone disease: a pilot study.J Clin Oncol. 2004; 22: 3587-3592
- High-dose intravenous pamidronate for metastatic bone pain.Brit J Cancer. 1994; 70: 554-558
- A randomized, placebo-controlled trial of zoledronic acid in patients with hormone-refractory metastatic prostate carcinoma.J Natl Cancer Inst. 2002; 94: 1458-1468
- Does supportive pamidronate treatment prevent or delay the first manifestation of bone metastases in breast cancer patients?.Eur J Cancer. 1996; 32A: 450-454
- Palliative pamidronate treatment in patients with bone metastases from breast cancer.J Clin Oncol. 1993; 11: 491-498
- The effect of supportive pamidronate treatment on aspects of quality of life of patients with advanced breast cancer.Eur J Cancer. 1991; 27: 544-549
- Zoledronic acid significantly improves pain scores and quality of life in breast cancer patients with bone metastases: a randomized, crossover study of community vs. hospital bisphosphonate administration.Brit J Cancer. 2005; 92: 1869-1876
- WHO Basic Documents, Geneva, Switzerland1948
- Quality of life and symptom measures in oncology: an overview.Am J Manage Care. 2002; 8: S560-S573
- Prophylactic management of impending fractures.in: Harrington K.D. Orthopedic management of metastatic bone disease. CV Mosby, 1988: 283-307
- The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology.J Natl Cancer Inst. 1993; 85: 365-376
- The European Organization for Research and Treatment of Cancer. Approach to quality of life assessment: guidelines for developing questionnaire modules. EORTC Study Group on Quality of Life.Qual Life Res. 1993; 2: 287-295
Blazeby J, Sprangers M, Cull A, et al. EORTC Quality of Life Group: guidelines for developing questionnaire modules. 3rd ed. revised. August 2002. <http://groups.eortc.be/qol/downloads/200208module_development_guidelines.pdf>.
- The development and utilization of the European Organisation for research and treatment of cancer quality of life group item bank.Eur J Cancer. 2002; 38: 1611-1614
- The EORTC QLQ-HDC29: a supplementary module assessing the quality of life during and after high-dose chemotherapy and stem cell transplantation.Eur J Cancer. 2007; 43: 87-94
Article info
Publication history
Published online: December 19, 2008
Accepted:
November 11,
2008
Received:
October 17,
2008
Identification
Copyright
© 2008 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
